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• W2887254100 abstract "Due to non-invasive nature of oral delivery and the fact that avoids patient pain and discomfort, so the oral method is one of the most commonly used. By consideration this aim, Cu-based metal-organic framework encapsulated ibuprofen (IBU) drug nanohybrid ([email protected]) protected with pH-sensitive biopolymeric carboxymethylcellulose (CMC) as a novel nanocomposite for oral delivery system was synthesized. The prepared hydrogel bead characterized using FT-IR, BET, XRD, UV–Vis spectroscopy and SEM analysis. The drug release tests showed that the CMC capsulated [email protected] nanocomposite hydrogel bead (CMC/[email protected]) has a better protection against stomach pH and extended the stability of drug dosing indeed it provides a controlled release in the gastrointestinal tract conditions. The MTT test demonstrated that the CMC/[email protected] has low toxicity against Caco-2 cells. According to the obtained results, the hydrogel bead could potentially use as an oral drug delivery system." @default.
• W2887254100 created "2018-08-22" @default.
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• W2887254100 date "2018-11-01" @default.
• W2887254100 modified "2023-10-16" @default.
• W2887254100 title "Carboxymethylcellulose capsulated Cu-based metal-organic framework-drug nanohybrid as a pH-sensitive nanocomposite for ibuprofen oral delivery" @default.
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• W2887254100 doi "https://doi.org/10.1016/j.ijbiomac.2018.07.181" @default.
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