FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887271916> ?p ?o ?g. }

• W2887271916 endingPage "422" @default.
• W2887271916 startingPage "408" @default.
• W2887271916 abstract "The mechanisms underpinning intrauterine growth restriction (IUGR), as a result of placental insufficiency, remain poorly understood, no specific treatment is available, and clinically useful biomarkers for early detection are lacking. We hypothesized that human IUGR is associated with inhibition of mechanistic target of rapamycin (mTOR) and activation of amino acid response (AAR) signaling, increased protein kinase casein kinase-2 (CK2) activity, and increased insulin-like growth factor-binding protein 1 (IGFBP-1) expression and phosphorylation in decidua and that maternal plasma IGFBP-1 hyperphosphorylation in the first trimester predicts later development of IUGR. Decidua [n = 16 appropriate-for-gestational age (AGA); n = 16 IUGR] and maternal plasma (n = 13 AGA; n = 13 IUGR) were collected at delivery from two different cohorts. In addition, maternal plasma was obtained in the late first trimester from a third cohort of women (n = 7) who later delivered an AGA or IUGR infant. Total IGFBP-1 expression and phosphorylation (Ser101/Ser119/Ser169), mTOR, AAR, and CK2 activity in decidua and IGFBP-1 concentration and phosphorylation in maternal plasma. We show that decidual IGFBP-1 expression and phosphorylation are increased, mTOR is markedly inhibited, and AAR and CK2 are activated in IUGR. Moreover, IGFBP-1 hyperphosphorylation in first-trimester maternal plasma is associated with the development of IUGR. These data are consistent with the possibility that the decidua functions as a nutrient sensor linking limited oxygen and nutrient availability to increased IGFBP-1 phosphorylation, possibly mediated by mTOR and AAR signaling. IGFBP-1 hyperphosphorylation in first-trimester maternal plasma may serve as a predictive IUGR biomarker, allowing early intervention." @default.
• W2887271916 created "2018-08-22" @default.
• W2887271916 creator A5005853438 @default.
• W2887271916 creator A5024848351 @default.
• W2887271916 creator A5038096153 @default.
• W2887271916 creator A5061273960 @default.
• W2887271916 creator A5065241845 @default.
• W2887271916 creator A5068691304 @default.
• W2887271916 creator A5084278759 @default.
• W2887271916 creator A5089750530 @default.
• W2887271916 date "2018-08-16" @default.
• W2887271916 modified "2023-10-14" @default.
• W2887271916 title "IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1" @default.
• W2887271916 cites W1598230405 @default.
• W2887271916 cites W171819190 @default.
• W2887271916 cites W1874090210 @default.
• W2887271916 cites W1903925749 @default.
• W2887271916 cites W1964880900 @default.
• W2887271916 cites W1980179310 @default.
• W2887271916 cites W1991922220 @default.
• W2887271916 cites W1994691538 @default.
• W2887271916 cites W2001867509 @default.
• W2887271916 cites W2004097699 @default.
• W2887271916 cites W2004204421 @default.
• W2887271916 cites W2006340617 @default.
• W2887271916 cites W2010378575 @default.
• W2887271916 cites W2011785882 @default.
• W2887271916 cites W2011861484 @default.
• W2887271916 cites W201920687 @default.
• W2887271916 cites W2021152062 @default.
• W2887271916 cites W2023331533 @default.
• W2887271916 cites W2037885071 @default.
• W2887271916 cites W2038343657 @default.
• W2887271916 cites W2039117147 @default.
• W2887271916 cites W2040336914 @default.
• W2887271916 cites W2040376617 @default.
• W2887271916 cites W2045350890 @default.
• W2887271916 cites W2049822369 @default.
• W2887271916 cites W2066559562 @default.
• W2887271916 cites W2073149084 @default.
• W2887271916 cites W2077166525 @default.
• W2887271916 cites W2079914895 @default.
• W2887271916 cites W2080330031 @default.
• W2887271916 cites W2084162834 @default.
• W2887271916 cites W2084181728 @default.
• W2887271916 cites W2093611899 @default.
• W2887271916 cites W2095243985 @default.
• W2887271916 cites W2096601431 @default.
• W2887271916 cites W2102496902 @default.
• W2887271916 cites W2105192683 @default.
• W2887271916 cites W2111353167 @default.
• W2887271916 cites W2114949397 @default.
• W2887271916 cites W2117162017 @default.
• W2887271916 cites W2118222394 @default.
• W2887271916 cites W2125012706 @default.
• W2887271916 cites W2125089843 @default.
• W2887271916 cites W2129843687 @default.
• W2887271916 cites W2132584096 @default.
• W2887271916 cites W2140269856 @default.
• W2887271916 cites W2142540964 @default.
• W2887271916 cites W214695330 @default.
• W2887271916 cites W2160209138 @default.
• W2887271916 cites W2169882453 @default.
• W2887271916 cites W2178653331 @default.
• W2887271916 cites W2203417024 @default.
• W2887271916 cites W2210816877 @default.
• W2887271916 cites W2276261647 @default.
• W2887271916 cites W2324229527 @default.
• W2887271916 cites W2358562921 @default.
• W2887271916 cites W2422505905 @default.
• W2887271916 cites W2471574565 @default.
• W2887271916 cites W2605446159 @default.
• W2887271916 cites W2606515107 @default.
• W2887271916 cites W2769762128 @default.
• W2887271916 cites W4302772252 @default.
• W2887271916 cites W2132774658 @default.
• W2887271916 doi "https://doi.org/10.1210/jc.2018-00820" @default.
• W2887271916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6306389" @default.
• W2887271916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30124960" @default.
• W2887271916 hasPublicationYear "2018" @default.
• W2887271916 type Work @default.
• W2887271916 sameAs 2887271916 @default.
• W2887271916 citedByCount "24" @default.
• W2887271916 countsByYear W28872719162018 @default.
• W2887271916 countsByYear W28872719162019 @default.
• W2887271916 countsByYear W28872719162020 @default.
• W2887271916 countsByYear W28872719162021 @default.
• W2887271916 countsByYear W28872719162022 @default.
• W2887271916 countsByYear W28872719162023 @default.
• W2887271916 crossrefType "journal-article" @default.
• W2887271916 hasAuthorship W2887271916A5005853438 @default.
• W2887271916 hasAuthorship W2887271916A5024848351 @default.
• W2887271916 hasAuthorship W2887271916A5038096153 @default.
• W2887271916 hasAuthorship W2887271916A5061273960 @default.
• W2887271916 hasAuthorship W2887271916A5065241845 @default.
• W2887271916 hasAuthorship W2887271916A5068691304 @default.
• W2887271916 hasAuthorship W2887271916A5084278759 @default.
• W2887271916 hasAuthorship W2887271916A5089750530 @default.

• next