Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887295684> ?p ?o ?g. }
- W2887295684 endingPage "4808" @default.
- W2887295684 startingPage "4803" @default.
- W2887295684 abstract "Abstract Epidemiologic studies are controversial concerning the roles played by cholesterol in cancer risk and development, possibly as it is not cholesterol per se that is pathologic in cancers. Indeed, recent data reveal that the cholesterol metabolism in cancer cells can generate endogenous oncopromoter metabolites at higher levels compared with normal tissues and/or can be deregulated in the production of endogenous oncosuppressor metabolites in an opposite way. These metabolites are oxysterols, which are cholesterol oxygenation products generated by enzymatic and/or autoxidation processes. All these oxysterols are new classes of estrogen, glucocorticoid, or liver X nuclear receptor ligands, and their protumor action on their cognate receptors could explain some drug resistance, while treatment with antitumor metabolites could complement their deficiency in cancers and restore their action on their nuclear receptor. Given that hypercholesterolemia and high intakes of cholesterol-rich foods or processed foods can generate these oxysterols, their importance in cancer risk or development in overweight and obese people is to be considered. The discovery of these cholesterol-derived metabolites and the identification of the nuclear receptors mediating their pro- or antitumor activities are important findings, which should have major implications in the diagnosis, prevention, and treatment of different cancers and open new areas of research. Cancer Res; 78(17); 4803–8. ©2018 AACR." @default.
- W2887295684 created "2018-08-22" @default.
- W2887295684 creator A5001428889 @default.
- W2887295684 creator A5057897776 @default.
- W2887295684 creator A5058791215 @default.
- W2887295684 date "2018-09-01" @default.
- W2887295684 modified "2023-10-18" @default.
- W2887295684 title "The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer" @default.
- W2887295684 cites W1850984254 @default.
- W2887295684 cites W1862564406 @default.
- W2887295684 cites W1969521020 @default.
- W2887295684 cites W1995424431 @default.
- W2887295684 cites W1996168740 @default.
- W2887295684 cites W2020879613 @default.
- W2887295684 cites W2034836489 @default.
- W2887295684 cites W2036192035 @default.
- W2887295684 cites W2044757108 @default.
- W2887295684 cites W2046994096 @default.
- W2887295684 cites W2053131885 @default.
- W2887295684 cites W2056657842 @default.
- W2887295684 cites W2058007868 @default.
- W2887295684 cites W2064188435 @default.
- W2887295684 cites W2070432942 @default.
- W2887295684 cites W2074108555 @default.
- W2887295684 cites W2081219398 @default.
- W2887295684 cites W2104505841 @default.
- W2887295684 cites W2111562236 @default.
- W2887295684 cites W2113362613 @default.
- W2887295684 cites W2115494022 @default.
- W2887295684 cites W2123002086 @default.
- W2887295684 cites W2150767516 @default.
- W2887295684 cites W2155240851 @default.
- W2887295684 cites W2225488124 @default.
- W2887295684 cites W2318531023 @default.
- W2887295684 cites W2384576046 @default.
- W2887295684 cites W2411345140 @default.
- W2887295684 cites W2464362159 @default.
- W2887295684 cites W2474711040 @default.
- W2887295684 cites W2509291718 @default.
- W2887295684 cites W2569244998 @default.
- W2887295684 cites W2591330736 @default.
- W2887295684 cites W2607056868 @default.
- W2887295684 cites W2672974621 @default.
- W2887295684 cites W2763638984 @default.
- W2887295684 cites W2768673582 @default.
- W2887295684 cites W2783471328 @default.
- W2887295684 cites W2792720753 @default.
- W2887295684 doi "https://doi.org/10.1158/0008-5472.can-18-1487" @default.
- W2887295684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30120211" @default.
- W2887295684 hasPublicationYear "2018" @default.
- W2887295684 type Work @default.
- W2887295684 sameAs 2887295684 @default.
- W2887295684 citedByCount "40" @default.
- W2887295684 countsByYear W28872956842019 @default.
- W2887295684 countsByYear W28872956842020 @default.
- W2887295684 countsByYear W28872956842021 @default.
- W2887295684 countsByYear W28872956842022 @default.
- W2887295684 countsByYear W28872956842023 @default.
- W2887295684 crossrefType "journal-article" @default.
- W2887295684 hasAuthorship W2887295684A5001428889 @default.
- W2887295684 hasAuthorship W2887295684A5057897776 @default.
- W2887295684 hasAuthorship W2887295684A5058791215 @default.
- W2887295684 hasConcept C104317684 @default.
- W2887295684 hasConcept C121608353 @default.
- W2887295684 hasConcept C126322002 @default.
- W2887295684 hasConcept C134018914 @default.
- W2887295684 hasConcept C167400880 @default.
- W2887295684 hasConcept C170493617 @default.
- W2887295684 hasConcept C2778163477 @default.
- W2887295684 hasConcept C502942594 @default.
- W2887295684 hasConcept C530470458 @default.
- W2887295684 hasConcept C55493867 @default.
- W2887295684 hasConcept C63932345 @default.
- W2887295684 hasConcept C71924100 @default.
- W2887295684 hasConcept C84606932 @default.
- W2887295684 hasConcept C86339819 @default.
- W2887295684 hasConcept C86803240 @default.
- W2887295684 hasConcept C98274493 @default.
- W2887295684 hasConceptScore W2887295684C104317684 @default.
- W2887295684 hasConceptScore W2887295684C121608353 @default.
- W2887295684 hasConceptScore W2887295684C126322002 @default.
- W2887295684 hasConceptScore W2887295684C134018914 @default.
- W2887295684 hasConceptScore W2887295684C167400880 @default.
- W2887295684 hasConceptScore W2887295684C170493617 @default.
- W2887295684 hasConceptScore W2887295684C2778163477 @default.
- W2887295684 hasConceptScore W2887295684C502942594 @default.
- W2887295684 hasConceptScore W2887295684C530470458 @default.
- W2887295684 hasConceptScore W2887295684C55493867 @default.
- W2887295684 hasConceptScore W2887295684C63932345 @default.
- W2887295684 hasConceptScore W2887295684C71924100 @default.
- W2887295684 hasConceptScore W2887295684C84606932 @default.
- W2887295684 hasConceptScore W2887295684C86339819 @default.
- W2887295684 hasConceptScore W2887295684C86803240 @default.
- W2887295684 hasConceptScore W2887295684C98274493 @default.
- W2887295684 hasIssue "17" @default.
- W2887295684 hasLocation W28872956841 @default.
- W2887295684 hasLocation W28872956842 @default.
- W2887295684 hasOpenAccess W2887295684 @default.