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- W2887302040 abstract "Patients undergoing surgery can suffer from various complications, including post-operative bleeding, local or systematic infection, and neurologic disorders. Major surgery can initiate innate immune responses and trigger overproduction of inflammatory mediators, which can contribute to organ dysfunction. Inflammasomes are innate immune complexes, which are connected to the pathogenesis of various diseases, including atherosclerosis, hemorrhagic brain injury, and Alzheimer’s disease. In the present study, we hypothesized that nucleotide-binding oligomerization domain-containing-like receptor protein (NLRP) inflammasomes may have a role in the pathological effects of surgery. Therefore, we designed a protein inhibitor of nuclear factor kappa B (NF-κB) p65 transcripts, called nt-p65-TMD (nuclear transducible (nt) transcription modulated domain (TMD) of RelA (p65)), that can penetrate the nucleus, and evaluated its therapeutic efficacy for dampening surgery-induced inflammasome activation. It was found that the nt-p65-TMD significantly reduced the NLRP1 inflammasome complex components (NLRP1, ASC, and Caspase-1) and interleukin (IL)-1β and IL-18 productions in the spleen after surgery. In the spleen, specific cell population and selective mediators were altered after surgery with/without nt-p65-TMD treatment. Also, we found that treatment of nt-p65-TMD decreased cell death in the spleen after surgery. Therefore, nt-p65-TMD is a potential novel strategy for reducing surgery-induced NLRP1 inflammasome and complications." @default.
- W2887302040 created "2018-08-22" @default.
- W2887302040 creator A5002387910 @default.
- W2887302040 creator A5022918002 @default.
- W2887302040 creator A5032688550 @default.
- W2887302040 creator A5047330848 @default.
- W2887302040 creator A5071928897 @default.
- W2887302040 creator A5073116220 @default.
- W2887302040 creator A5083693207 @default.
- W2887302040 creator A5088481989 @default.
- W2887302040 date "2018-12-01" @default.
- W2887302040 modified "2023-09-26" @default.
- W2887302040 title "Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery" @default.
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