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- W2887335086 abstract "The purpose of this research was to develop multiple-unit gastric floating mini-tablets and to evaluate the possibility of using these mini-tablets as a delivery system to improve the drug absorption for drugs with a narrow absorption window. Mini-tablets were prepared using hydroxypropyl methylcellulose (HPMC K100M) and carbopol 971P as release retarding agents and sodium bicarbonate (NaHCO3) as gas-forming agent. The properties of the prepared mini-tablets in terms of floating characteristic parameters and in vitro release were evaluated. Furthermore, in vivo gastric retention study in rats and in vivo pharmacokinetic study in rabbits of the optimized formulation were performed. The optimized mini-tablets containing 45% HPMC K100M, 15% stearyl alcohol, 13% carbopol 971P, and 12% NaHCO3 were found to float immediately within 1 min and duration more than 9 h. The in vivo gastric retention study results indicated that the mini-tablets could retain in the stomach for more than 6.67 h. Furthermore, the AUC0−t of the floating mini-tablets (6849.83 ± 753.80 h ng·mL−1) was significantly higher than that of marketed sustained-release tablets XATRAL®XL (4970.16 ± 924.60 h ng·mL−1). All these results illustrated that the gastric floating mini-tablets might be a promising drug delivery system for drugs with a narrow absorption window." @default.
- W2887335086 created "2018-08-22" @default.
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- W2887335086 date "2018-09-17" @default.
- W2887335086 modified "2023-09-28" @default.
- W2887335086 title "Design and optimization of gastric floating sustained-release mini-tablets of alfuzosin hydrochloride based on a factorial design: <i>in vitro/in vivo</i> evaluation" @default.
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- W2887335086 doi "https://doi.org/10.1080/03639045.2018.1506473" @default.
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