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- W2887350468 abstract "BACKGROUND OF THE STUDY :In essential hypertension, the comorbidity of hyperuricaemia is very common whichleads to cardiovascular morbidity. So the present study was done to focus on the uricosuric effectof losartan in newly diagnosed hypertensive patients with hyperuricaemia.OBJECTIVES :1. Changes in serum uric acid & urinary uric acid excretion from baseline to the endpoint.2. Changes in blood pressure and lipid profile from baseline to the endpoint.3. Improvement in quality of life score.4. Tolerability of tablet losartan.METHODOLOGY :Fifty four hypertensive patients with hyperuricaemia who fulfilled the eligible criteria wereincluded in the study.All the study participants were given T.Losartan 50mg once daily for fourweeks. At the end of 1st,2nd, 3rd and 4th week blood pressure control, tolerance and compliancewere monitored. At the end of 4th week all the baseline laboratory parameters like renal functiontest, liver function test, lipid prolife, random blood sugar, serum uric acid and urinary uric acidelimination were performed. The EQ-5D questionnaires were completed at two points in thestudy time: at the patient’s initial visit and after 4 weeks of Losartan therapy.RESULTS :The results were statistically analysed. There was statistically significant reduction in meanserum uric acid from 6.43mg/dl to 5.33mg/dl with p<0.0001. The mean urinary uric acidexcretion was increased from 418.12mg/day to 467.84md/day which was statistically significant(p<0.001). The mean systolic blood pressure,diastolic blood pressure and lipid profile values werereduced significantly with p<0.0001. Improvements in the QOL parameters, paralleled withimprovement of the clinical picture.Losartan was well tolerated.CONCLUSION :Losartan is safe and effective in treating hypertensive patients with hyperuricaemia due to itsuricosuric effect and it also has benefits of reducing serum glucose, lipid levels; andimprovement in the quality of life." @default.
- W2887350468 created "2018-08-22" @default.
- W2887350468 creator A5071703965 @default.
- W2887350468 date "2017-04-01" @default.
- W2887350468 modified "2023-09-26" @default.
- W2887350468 title "An Open Label Prospective Study on Uricosuric Effects of Losartan in Hypertensive Patients with Hyperuricaemia" @default.
- W2887350468 hasPublicationYear "2017" @default.
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