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• W2887352213 abstract "Cervical Cancer Is The Third Most Common Cancer AmongWomen Worldwide & Second Most Common Cancer In DevelopingCountries, Over Half Of Which Are Fatal (Jemal A Et Al 2011)1. About 80%Of These Cases And Deaths Occurred In Developing Countries (Ferlay Et Al2010)2.This High Mortality Makes Cervical Cancer An Important PublicHealth Problem. Cervical Cancer Is Slow Growing And Hence Has PotentialFor Effective Prevention Through Various Screening Procedures. CervicalCytology Has Proved To Be One Of The Most Successful Examples Of CancerScreening In Many Developed Countries And Has Resulted In SignificantDecrease In Incidence And Mortality From Invasive Cancer By Detecting AndEradicating The Pre Invasive Lesions (Clarke EA 1979)3(Hakama M Et Al1985)4(Miller AB Et Al 1990)5 (Mathew A Et Al 2009)6.Invasive Cervical Cancer Is The End Result Of A Long PathologicalProcess That Begins With Precursor Lesion Called Squamous IntraepithelialLesions .Early Changes In The Cervix In The Form Of CIN Can Be DetectedYears Before Invasive Carcinoma Develops And This Is The Basis OfEffectiveness Of Cytological Screening (Wright T Et Al 1994)7. The MainObjective Of Cervical Screening Is To Decrease Worldwide Incidence AndMortality Of Cervical Cancer, By Detecting And Treating PrecancerousLesions.The Screening Of Cervical Cytology Smears Was Introduced In 1928By Dr.George N.Papanicolaou When He Reported The Observation OfDysplastic/Malignant Cells In Women With Cervical Cancer By SamplingVaginal Smears. Subsequently Papanicolaou And Dr.Herbert TrautIdentified Cells Of Both Invasive And Pre Invasive Cervical NeoplasticLesions By Cervical Cytology. This Test Is Now Known As The ConventionalPap Smear Or Pap Test (Papanicolaou Et Al 1941)8.For Conventional Cervical Cytology Cell Samples Taken From TheCervix By Using Ayre’s Spatula Is Smeared Onto Slides, Fixed And StainedWith Papanicolaou Stain. Specificity Of This Test Is 98 To 99%. But TheSensitivity, Ranges From 50%-75% (Fahey MT Et Al 1995)9(Nanda K Et Al2000)10. Several Limitations Of Conventional Pap Test Are Identified Such As1) Inadequate Transfer Of Cells To Slide, 2) Un Uniform Distribution OfAbnormal Cells, 3) Presence Of Obscuring Inflammation, Blood AndOverlapping Of Epithelial Cells (Richart RM Et Al 1965)11.Liquid Based Thin Layer Technology Was Introduced As A FDAApproved Alternative Method To Conventional Pap In 1996 To Address TheseLimitations. The First Generation Automated Liquid-Based Cytology (LBC)Involves Rinsing The Sampling Device Into A Vial Of Fixative To Form ASuspension Of Cells From Which A Monolayer Of Cells On A Slide IsPrepared. These Slides Can Be Read More Quickly Than ConventionalSmears & The Residual Sample Can Be Used For HPV DNA Testing. ThereAre Two Methods Of FDA Approved LBC Technologies -Thinprep AndSurepath (Lee RL Et Al 1997)12 (Monsonego J Et Al 2001)13(Fang-HuiZhao Et Al 2011)14.These New LBC Techniques Require An AutomatedInstrument And So Higher Cost Per Test.Liquiprep, The Second Generation Liquid Based Cytology SystemEliminates Most Of The Instruments Required By The First GenerationTechniques Thereby Offering A Simpler Method With Lower Costs ForCervical Cancer Screening. Liquiprep System Consist Of Fixative Fluid Vial,A Cleaning Solution & A Cell Base That Act As A Membrane Matrix ToProduce A Monolayer Of Cells(Geyer J Et Al 2004)15. Easy Method OfPreparation & High Correlation Of Results Obtained With CS Makes ThisMethod Highly Suitable For Cervical Cytology In Developing Countries(Jongkolnee Settakorn Et Al 2008)16.There Are A Few Studies Showing An Indigenous Method Of LiquidBased Cytology Called Manual Liquid Based Cytology (MLBC). In ThisMethod Chemicals Available In Their Own Laboratory Were Used To PrepareFixative And Polymer Solution And Use Simple Equipments To PrepareCervical Smear Slides. This Is A Low Cost Method Of Cervical Pap SmearScreening (Maksem Et Al 2001)17 (Maksem Et Al 2005)18 (Lee Et Al2006)19(Kavatkar Et Al 2008)20(Nandini Et Al 2012) 21.The Present Study Was Undertaken To Compare This Low Cost ManualLBC With Conventional Pap Cytology .In Addition We Also ComparedSecond Generation Liquiprep System With Conventional Smears." @default.
• W2887352213 created "2018-08-22" @default.
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• W2887352213 date "2013-04-01" @default.
• W2887352213 modified "2023-09-26" @default.
• W2887352213 title "Liquid Based Cytology over Conventional Pap StainingMethod in Evaluating Cervical Smears." @default.
• W2887352213 hasPublicationYear "2013" @default.
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