FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887361276> ?p ?o ?g. }

• W2887361276 endingPage "1861" @default.
• W2887361276 startingPage "1851" @default.
• W2887361276 abstract "Liver, as one of the most important organs involved in lipids and glucose metabolism, is perceived as a key tissue for pharmacotherapy of insulin resistance (IRes) and type 2 diabetes. Ceramides (Cer) are biologically active lipids, which accumulation is associated with the induction of muscle IRes. We sought to determine the role of intrahepatic bioactive lipids production on insulin action in liver of insulin‐resistant rats and after myriocin administration. The experiments were conducted on male Wistar rats divided into three groups: Control, fed high‐fat diet (HFD), and fed HFD and treated with myriocin (HFD/Myr). Before sacrifice, the animals were infused with a [U‐ 13 C]palmitate to calculate lipid synthesis rate by means of tracer incorporation technique in particular lipid groups. Liver Cer, diacylglycerols (DAG), acyl‐carnitine concentration, and isotopic enrichment were analyzed by LC/MS/MS. Proteins involved in lipid metabolism and insulin pathway were analyzed by western blot analysis. An OGTT and ITT was also performed. HFD‐induced IRes and increased both the synthesis rate and the content of DAG and Cer, which was accompanied by inhibition of an insulin pathway. Interestingly, myriocin treatment reduced synthesis rate not only of Cer but also DAG and improved insulin sensitivity. We conclude that the insulin‐sensitizing action of myriocin in the liver is a result of the lack of inhibitory effect of lipids on the insulin pathway, due to the reduction of their synthesis rate. This is the first study showing how the synthesis rate of individual lipid groups in liver changes after myriocin administration." @default.
• W2887361276 created "2018-08-22" @default.
• W2887361276 creator A5005677739 @default.
• W2887361276 creator A5006970207 @default.
• W2887361276 creator A5024823786 @default.
• W2887361276 creator A5075231467 @default.
• W2887361276 creator A5081147754 @default.
• W2887361276 creator A5088772738 @default.
• W2887361276 date "2018-08-01" @default.
• W2887361276 modified "2023-09-26" @default.
• W2887361276 title "The effect of high‐fat diet and inhibition of ceramide production on insulin action in liver" @default.
• W2887361276 cites W1555673341 @default.
• W2887361276 cites W1608393181 @default.
• W2887361276 cites W1780976067 @default.
• W2887361276 cites W1973939264 @default.
• W2887361276 cites W1975718861 @default.
• W2887361276 cites W1984199902 @default.
• W2887361276 cites W1985592156 @default.
• W2887361276 cites W1994246552 @default.
• W2887361276 cites W1995687483 @default.
• W2887361276 cites W1999087996 @default.
• W2887361276 cites W2003755391 @default.
• W2887361276 cites W2012295774 @default.
• W2887361276 cites W2020799782 @default.
• W2887361276 cites W2022982729 @default.
• W2887361276 cites W2033125833 @default.
• W2887361276 cites W2039963918 @default.
• W2887361276 cites W2047665886 @default.
• W2887361276 cites W2049753884 @default.
• W2887361276 cites W2053753878 @default.
• W2887361276 cites W2067729580 @default.
• W2887361276 cites W2072268442 @default.
• W2887361276 cites W2073656642 @default.
• W2887361276 cites W2076091755 @default.
• W2887361276 cites W2080955035 @default.
• W2887361276 cites W2086102771 @default.
• W2887361276 cites W2086279639 @default.
• W2887361276 cites W2094051977 @default.
• W2887361276 cites W2094068658 @default.
• W2887361276 cites W2104215422 @default.
• W2887361276 cites W2106368473 @default.
• W2887361276 cites W2107021176 @default.
• W2887361276 cites W2108904664 @default.
• W2887361276 cites W2123521914 @default.
• W2887361276 cites W2126317966 @default.
• W2887361276 cites W2127056938 @default.
• W2887361276 cites W2131149701 @default.
• W2887361276 cites W213235476 @default.
• W2887361276 cites W2144848086 @default.
• W2887361276 cites W2146845495 @default.
• W2887361276 cites W2155519776 @default.
• W2887361276 cites W2157559566 @default.
• W2887361276 cites W2161296874 @default.
• W2887361276 cites W2171407792 @default.
• W2887361276 cites W2200705322 @default.
• W2887361276 cites W2259778815 @default.
• W2887361276 cites W2280335492 @default.
• W2887361276 cites W2282032965 @default.
• W2887361276 cites W2346621933 @default.
• W2887361276 cites W2404036442 @default.
• W2887361276 cites W2566170273 @default.
• W2887361276 cites W2614501264 @default.
• W2887361276 cites W2772862192 @default.
• W2887361276 cites W2802770581 @default.
• W2887361276 cites W30399182 @default.
• W2887361276 doi "https://doi.org/10.1002/jcp.27058" @default.
• W2887361276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30067865" @default.
• W2887361276 hasPublicationYear "2018" @default.
• W2887361276 type Work @default.
• W2887361276 sameAs 2887361276 @default.
• W2887361276 citedByCount "27" @default.
• W2887361276 countsByYear W28873612762018 @default.
• W2887361276 countsByYear W28873612762019 @default.
• W2887361276 countsByYear W28873612762020 @default.
• W2887361276 countsByYear W28873612762021 @default.
• W2887361276 countsByYear W28873612762022 @default.
• W2887361276 countsByYear W28873612762023 @default.
• W2887361276 crossrefType "journal-article" @default.
• W2887361276 hasAuthorship W2887361276A5005677739 @default.
• W2887361276 hasAuthorship W2887361276A5006970207 @default.
• W2887361276 hasAuthorship W2887361276A5024823786 @default.
• W2887361276 hasAuthorship W2887361276A5075231467 @default.
• W2887361276 hasAuthorship W2887361276A5081147754 @default.
• W2887361276 hasAuthorship W2887361276A5088772738 @default.
• W2887361276 hasConcept C126322002 @default.
• W2887361276 hasConcept C134018914 @default.
• W2887361276 hasConcept C17093226 @default.
• W2887361276 hasConcept C185592680 @default.
• W2887361276 hasConcept C190283241 @default.
• W2887361276 hasConcept C2777391703 @default.
• W2887361276 hasConcept C2777851122 @default.
• W2887361276 hasConcept C2779306644 @default.
• W2887361276 hasConcept C4733338 @default.
• W2887361276 hasConcept C55493867 @default.
• W2887361276 hasConcept C62231903 @default.
• W2887361276 hasConcept C71924100 @default.
• W2887361276 hasConcept C86803240 @default.
• W2887361276 hasConceptScore W2887361276C126322002 @default.

• next