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• W2887364036 abstract "A small percentage (8%) of the captive-bred vervet monkeys (Chlorocebus aethiops)maintained at Primate Unit and Delft Animal Centre (PUDAC) of the South African MedicalResearch Council (SAMRC) were found to have high levels of glycine in their plasma (457-795 ?mol/L) and cerebrospinal fluid (CSF) (7.5-12.7 ?mol/L). Additionally, thesehyperglycinemic monkeys developed cataracts, a condition which has been previouslycharacterized and reported in this specific colony of captive-bred vervet monkeys. This type ofassociation has never been reported in literature before, therefore, this study will be the first ofits kind to be investigated in non-human primates (NHPs). Nonketotic hyperglycinemia(NKH), also known as glycine encephalopathy, is well characterised in humans. The symptomsare exclusively neurological in nature, and clinically patients are diagnosed with abnormallyhigh glycine levels in plasma (normal <350 ?mol/L) and CSF (normal range 0-8). Thisneurological disorder is transmitted in an autosomal recessive form and is mainly instigated bya defective glycine cleavage system (GCS). In contrast to GCS, glycine transporter (GlyT1)which regulates glycine concentration at synapses and valproate administration have beenassociated with NKH." @default.
• W2887364036 created "2018-08-22" @default.
• W2887364036 creator A5086692207 @default.
• W2887364036 date "2017-01-01" @default.
• W2887364036 modified "2023-09-23" @default.
• W2887364036 title "Hyperglycinemia in captive-bred vervet monkeys with cataracts: genetic dynamics and associations" @default.
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