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- W2887364413 abstract "Abstract Protein misfolding and aggregation are associated with a number of human degenerative diseases. In spite of the enormous research efforts to develop effective strategies aimed at interfering with the pathogenic cascades induced by misfolded/aggregated peptides/proteins, the necessary detailed understanding of the molecular bases of amyloid formation and toxicity is still lacking. To this aim, approaches able to provide a global insight in amyloid-mediated physiological alterations are of importance. In this study, we exploited Fourier transform infrared microspectroscopy, supported by multivariate analysis, to investigate in situ the spectral changes occurring in cultured intact HL-1 cardiomyocytes exposed to wild type (WT) or mutant (L55P) transthyretin (TTR) in native, or amyloid conformation. The presence of extracellular deposits of amyloid aggregates of WT or L55P TTR, respectively, is a key hallmark of two pathological conditions, known as senile systemic amyloidosis and familial amyloid polyneuropathy. We found that the major effects, associated with modifications in lipid properties and in the cell metabolic/phosphorylation status, were observed when natively folded WT or L55P TTR was administered to the cells. The effects induced by aggregates of TTR were milder and in some cases displayed a different timing compared to those elicited by the natively folded protein." @default.
- W2887364413 created "2018-08-22" @default.
- W2887364413 creator A5015795505 @default.
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- W2887364413 date "2018-08-21" @default.
- W2887364413 modified "2023-09-26" @default.
- W2887364413 title "A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes" @default.
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- W2887364413 doi "https://doi.org/10.1038/s41598-018-30995-5" @default.
- W2887364413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6104026" @default.
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- W2887364413 hasPublicationYear "2018" @default.
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