FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887370546> ?p ?o ?g. }

• W2887370546 endingPage "4717" @default.
• W2887370546 startingPage "4701" @default.
• W2887370546 abstract "Abstract Nuclear factor of activated T cells ( NFAT ) is a family of transcription factors that have important functions in many tumors. However, the expression level and functional role of NFAT in hepatocellular carcinoma ( HCC ) remain unclear. In this study, we showed that NFAT c1 expression was decreased in both HCC tissues and cell lines. Low expression of NFAT c1 was correlated with larger tumor size, advanced tumor‐node‐metastasis ( TNM ) stage, high serum AFP level, and liver cirrhosis. Furthermore, patients with low NFAT c1 expression exhibited poor prognosis. Ectopic expression of NFAT c1 in HCC cells inhibited proliferation and colony formation, leading to G1 arrest and induction of apoptosis. In addition, we demonstrated that NFAT c1 increased Fas ligand (FasL) expression by directly binding to its promoter and activated the extrinsic apoptotic pathway. NFAT c1 and FasL expression patterns and their prognostic value for patients with HCC were also evaluated in TCGA Liver Hepatocellular Carcinoma database. Knock‐down of FasL expression by si RNA in HCC cell lines abolished NFAT c1's antiproliferative and pro‐apoptotic effects. In conclusion, NFAT c1 is frequently inactivated in HCC and functions as a tumor suppressor in liver carcinogenesis. Ectopic expression of NFAT c1 in HCC cells induces apoptosis by activating the FasL‐mediated extrinsic signaling pathway." @default.
• W2887370546 created "2018-08-22" @default.
• W2887370546 creator A5015848447 @default.
• W2887370546 creator A5036207128 @default.
• W2887370546 creator A5036862777 @default.
• W2887370546 creator A5044025514 @default.
• W2887370546 creator A5046436076 @default.
• W2887370546 creator A5055174519 @default.
• W2887370546 creator A5061331252 @default.
• W2887370546 creator A5076466558 @default.
• W2887370546 date "2018-08-07" @default.
• W2887370546 modified "2023-10-03" @default.
• W2887370546 title "<scp>NFAT</scp>c1 is a tumor suppressor in hepatocellular carcinoma and induces tumor cell apoptosis by activating the FasL‐mediated extrinsic signaling pathway" @default.
• W2887370546 cites W1494629114 @default.
• W2887370546 cites W1521598031 @default.
• W2887370546 cites W1745634660 @default.
• W2887370546 cites W1960096185 @default.
• W2887370546 cites W1964562088 @default.
• W2887370546 cites W1965613016 @default.
• W2887370546 cites W1966584824 @default.
• W2887370546 cites W1992873835 @default.
• W2887370546 cites W2001246952 @default.
• W2887370546 cites W2004466285 @default.
• W2887370546 cites W2004720912 @default.
• W2887370546 cites W2005476912 @default.
• W2887370546 cites W2006641696 @default.
• W2887370546 cites W2012401419 @default.
• W2887370546 cites W2017032292 @default.
• W2887370546 cites W2029024519 @default.
• W2887370546 cites W2039691470 @default.
• W2887370546 cites W2048085771 @default.
• W2887370546 cites W2049856484 @default.
• W2887370546 cites W2053965379 @default.
• W2887370546 cites W2058088852 @default.
• W2887370546 cites W2059894395 @default.
• W2887370546 cites W2059912147 @default.
• W2887370546 cites W2061725286 @default.
• W2887370546 cites W2063692415 @default.
• W2887370546 cites W2065014879 @default.
• W2887370546 cites W2068547732 @default.
• W2887370546 cites W2073580835 @default.
• W2887370546 cites W2080319341 @default.
• W2887370546 cites W2082427996 @default.
• W2887370546 cites W2092697214 @default.
• W2887370546 cites W2099609360 @default.
• W2887370546 cites W2101855645 @default.
• W2887370546 cites W2102941331 @default.
• W2887370546 cites W2105552270 @default.
• W2887370546 cites W2119827505 @default.
• W2887370546 cites W2122948626 @default.
• W2887370546 cites W2133420817 @default.
• W2887370546 cites W2142837526 @default.
• W2887370546 cites W2151501496 @default.
• W2887370546 cites W2152473626 @default.
• W2887370546 cites W2157973267 @default.
• W2887370546 cites W2159266018 @default.
• W2887370546 cites W2180308778 @default.
• W2887370546 cites W2277164145 @default.
• W2887370546 cites W2476137399 @default.
• W2887370546 cites W2529646902 @default.
• W2887370546 cites W2529977469 @default.
• W2887370546 cites W2592403778 @default.
• W2887370546 doi "https://doi.org/10.1002/cam4.1716" @default.
• W2887370546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143940" @default.
• W2887370546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30085405" @default.
• W2887370546 hasPublicationYear "2018" @default.
• W2887370546 type Work @default.
• W2887370546 sameAs 2887370546 @default.
• W2887370546 citedByCount "20" @default.
• W2887370546 countsByYear W28873705462018 @default.
• W2887370546 countsByYear W28873705462019 @default.
• W2887370546 countsByYear W28873705462020 @default.
• W2887370546 countsByYear W28873705462021 @default.
• W2887370546 countsByYear W28873705462022 @default.
• W2887370546 countsByYear W28873705462023 @default.
• W2887370546 crossrefType "journal-article" @default.
• W2887370546 hasAuthorship W2887370546A5015848447 @default.
• W2887370546 hasAuthorship W2887370546A5036207128 @default.
• W2887370546 hasAuthorship W2887370546A5036862777 @default.
• W2887370546 hasAuthorship W2887370546A5044025514 @default.
• W2887370546 hasAuthorship W2887370546A5046436076 @default.
• W2887370546 hasAuthorship W2887370546A5055174519 @default.
• W2887370546 hasAuthorship W2887370546A5061331252 @default.
• W2887370546 hasAuthorship W2887370546A5076466558 @default.
• W2887370546 hasBestOaLocation W28873705461 @default.
• W2887370546 hasConcept C126322002 @default.
• W2887370546 hasConcept C128057223 @default.
• W2887370546 hasConcept C189938988 @default.
• W2887370546 hasConcept C190283241 @default.
• W2887370546 hasConcept C2778019345 @default.
• W2887370546 hasConcept C2911091166 @default.
• W2887370546 hasConcept C31573885 @default.
• W2887370546 hasConcept C502942594 @default.
• W2887370546 hasConcept C54355233 @default.
• W2887370546 hasConcept C55493867 @default.
• W2887370546 hasConcept C62112901 @default.
• W2887370546 hasConcept C62478195 @default.
• W2887370546 hasConcept C66008609 @default.

• next