FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887382535> ?p ?o ?g. }

• W2887382535 abstract "Iron deficiency is one of the most common nutritional deficiencies, and has a number of physiological manifestations. Early, or non-anaemic iron deficiency can result in fatigue and diminished exercise capacity. Oral iron preparations have a high incidence of intolerable side effects, and are ineffective in certain forms of iron deficiency. Consequently, intravenous iron preparations are increasingly used in the treatment of non-anaemic iron deficiency. The newer, more stable iron preparations in particular purport to have a lower incidence of side effects, and are now used across a range of different patient populations.To assess the effects of intravenous iron therapy in the treatment of adults with non-anaemic iron deficiency.On 18 October 2019 we electronically searched CENTRAL, MEDLINE, Embase, two further databases and two trials registries 2019. We handsearched the references of full-text extracted studies, and contacted relevant study authors for additional data.We included randomised controlled trials that compared any intravenous iron preparation to placebo in adults. We excluded other forms of comparison such as oral iron versus placebo, intramuscular iron versus placebo, or intravenous iron studies where other iron preparations were used as the comparator. We also excluded studies involving erythropoietin therapy or obstetric populations.Two review authors screened references for eligibility, extracted data and assessed risk of bias. We resolved differences in opinion through discussion and consensus, and where necessary, involved a third review author to adjudicate disputes. We contacted study authors to request additional data where appropriate. The primary outcome measures were haemoglobin concentration at the end of follow-up, and quality-of-life scores at end of follow-up. Secondary outcome measures were serum ferritin, peak oxygen consumption (as measured by cardiopulmonary exercise testing), adverse effects (graded as mild to moderate and severe) and bacterial infection. We pooled data for continuous outcomes, which we then reported as mean differences (MDs) with 95% confidence intervals (CIs). We reported quality-of-life metrics as standardised mean difference (SMD), and then converted them back into a more familiar measure, the Piper Fatigue Scale. We analysed dichotomous outcomes as risk ratios (RRs). Given an expected degree of heterogeneity, we used a random-effects model for all outcomes. We performed the analysis with the software package Review Manager 5.This review includes 11 studies with 1074 participants. Outcome metrics for which data were available (haemoglobin concentration, quality-of-life scores, serum ferritin, peak oxygen consumption and mild to moderate adverse effects) were similar across the included studies. The incidence of severe adverse events across all studies was zero. None of the studies measured bacterial infection as a specific outcome metric. Substantial heterogeneity influenced the results of the meta-analysis, arising from differing patient populations, definitions of iron deficiency, iron preparations and dosing regimens, and time to end of follow-up. Consequently, many outcomes are reported with small group sizes and wide confidence intervals, with a subsequent downgrading in the quality of evidence. The level of bias in many included studies was high, further reducing confidence in the robustness of the results. We found that intravenous iron therapy may lead to a small increase in haemoglobin concentration of limited clinical significance compared to placebo (MD 3.04 g/L, 95% CI 0.65 to 5.42; I2 = 42%; 8 studies, 548 participants; low-quality evidence). Quality-of-life scores (Piper Fatigue Scale MD 0.73, 95% CI 0.29 to 1.18; I2 = 0%; studies = 3) and peak oxygen consumption (MD 2.77 mL/kg/min, 95% CI -0.89 to 6.43; I2 = 36%; 2 studies, 32 participants) were associated with very low-quality evidence, and we remain uncertain about the role of intravenous iron for these metrics. We were unable to present pooled estimates for the outcomes of serum ferritin at the end of follow-up or mild to moderate adverse effects due to extreme statistical heterogeneity. Ultimately, despite the results of the meta-analysis, the low- or very low-quality evidence for all outcomes precludes any meaningful interpretation of results beyond suggesting that further research is needed. We performed a Trial Sequential Analysis for all major outcomes, none of which could be said to have reached a necessary effect size.Current evidence is insufficient to show benefit of intravenous iron preparations for the treatment of non-anaemic iron deficiency across a variety of patient populations, beyond stating that it may result in a small, clinically insignificant increase in haemoglobin concentration. However, the certainty for even this outcome remains limited. Robust data for the effectiveness of intravenous iron for non-anaemic iron deficiency is still lacking, and larger studies are required to assess the effect of this therapy on laboratory, patient-centric, and adverse-effect outcomes." @default.
• W2887382535 created "2018-08-22" @default.
• W2887382535 creator A5016293659 @default.
• W2887382535 creator A5045805117 @default.
• W2887382535 creator A5069617226 @default.
• W2887382535 creator A5081749322 @default.
• W2887382535 date "2019-12-20" @default.
• W2887382535 modified "2023-09-27" @default.
• W2887382535 title "Intravenous iron therapy for non-anaemic, iron-deficient adults" @default.
• W2887382535 cites W1209976727 @default.
• W2887382535 cites W162181629 @default.
• W2887382535 cites W1638373457 @default.
• W2887382535 cites W1723550313 @default.
• W2887382535 cites W1761222131 @default.
• W2887382535 cites W1822851295 @default.
• W2887382535 cites W1870257566 @default.
• W2887382535 cites W1900257882 @default.
• W2887382535 cites W1907209151 @default.
• W2887382535 cites W1934038521 @default.
• W2887382535 cites W1960055422 @default.
• W2887382535 cites W1972540879 @default.
• W2887382535 cites W1972652104 @default.
• W2887382535 cites W1980042430 @default.
• W2887382535 cites W1980082043 @default.
• W2887382535 cites W1987433088 @default.
• W2887382535 cites W1997355335 @default.
• W2887382535 cites W2006187515 @default.
• W2887382535 cites W2007440356 @default.
• W2887382535 cites W2009233748 @default.
• W2887382535 cites W2009761840 @default.
• W2887382535 cites W2009878128 @default.
• W2887382535 cites W2019599941 @default.
• W2887382535 cites W2021092349 @default.
• W2887382535 cites W2025063713 @default.
• W2887382535 cites W2028265881 @default.
• W2887382535 cites W2037615720 @default.
• W2887382535 cites W2039385278 @default.
• W2887382535 cites W2046551865 @default.
• W2887382535 cites W2048837770 @default.
• W2887382535 cites W2055469806 @default.
• W2887382535 cites W2059230191 @default.
• W2887382535 cites W2062704571 @default.
• W2887382535 cites W2073271820 @default.
• W2887382535 cites W2078629931 @default.
• W2887382535 cites W2087734261 @default.
• W2887382535 cites W2090426855 @default.
• W2887382535 cites W2092480503 @default.
• W2887382535 cites W2094682665 @default.
• W2887382535 cites W2096053912 @default.
• W2887382535 cites W2106284588 @default.
• W2887382535 cites W2107504607 @default.
• W2887382535 cites W2108335857 @default.
• W2887382535 cites W2109305563 @default.
• W2887382535 cites W2111224035 @default.
• W2887382535 cites W2116642832 @default.
• W2887382535 cites W2118110095 @default.
• W2887382535 cites W2121584920 @default.
• W2887382535 cites W2123200029 @default.
• W2887382535 cites W2123470679 @default.
• W2887382535 cites W2125435699 @default.
• W2887382535 cites W2126707535 @default.
• W2887382535 cites W2132155262 @default.
• W2887382535 cites W2135885870 @default.
• W2887382535 cites W2139318112 @default.
• W2887382535 cites W2140582054 @default.
• W2887382535 cites W2148669301 @default.
• W2887382535 cites W2156098321 @default.
• W2887382535 cites W2157823046 @default.
• W2887382535 cites W2159738034 @default.
• W2887382535 cites W2161897724 @default.
• W2887382535 cites W2164481110 @default.
• W2887382535 cites W2168095126 @default.
• W2887382535 cites W2174036561 @default.
• W2887382535 cites W2276227009 @default.
• W2887382535 cites W2286194308 @default.
• W2887382535 cites W2293362500 @default.
• W2887382535 cites W2321770168 @default.
• W2887382535 cites W2395484467 @default.
• W2887382535 cites W2428460729 @default.
• W2887382535 cites W2438097307 @default.
• W2887382535 cites W246286872 @default.
• W2887382535 cites W2492586169 @default.
• W2887382535 cites W2508442572 @default.
• W2887382535 cites W2525452034 @default.
• W2887382535 cites W2529449813 @default.
• W2887382535 cites W2546234166 @default.
• W2887382535 cites W2564223372 @default.
• W2887382535 cites W2567362164 @default.
• W2887382535 cites W2580449060 @default.
• W2887382535 cites W2594467170 @default.
• W2887382535 cites W2604862291 @default.
• W2887382535 cites W2669264138 @default.
• W2887382535 cites W2734960411 @default.
• W2887382535 cites W2754386136 @default.
• W2887382535 cites W2761746507 @default.
• W2887382535 cites W2766391942 @default.
• W2887382535 cites W2767726438 @default.
• W2887382535 cites W2770510338 @default.
• W2887382535 cites W2773059864 @default.
• W2887382535 cites W2775435138 @default.

• next