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- W2887424467 abstract "Introduction: Elasticity largely contributes to mechanical properties of the arteries and loss of elastic properties exacerbates aortic diseases, such as atherosclerosis or aortic aneurysms (AA). It is well known that prostaglandin E2 (PGE2) synthesis is enhanced in aortic diseases. We have demonstrated that the PGE2 receptor EP4 was abundantly expressed in smooth muscle cells (SMCs) from human AA tissues. Hypothesis: We examined whether PGE2-EP4 signaling in SMCs decreases elasticity in the aorta. Methods: We generated mice with vascular smooth muscle-specific overexpression of human EP4 using the Cre-loxP system (EP4loxP/-/SM22-Cre mice: EP4TG and EP4-/-/SM22-Cre mice: EP4NTG). Transcription profiles of the aorta were examined by quantitative RT-PCR and DNA microarray analyses. EP4 protein expression was examined by immunohistochemistry. Isometric tension of the aorta was measured using a wire myograph. Elasticity was evaluated by simultaneous measurement of dimension and pressure of the aorta under bas..." @default.
- W2887424467 created "2018-08-22" @default.
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- W2887424467 date "2013-11-26" @default.
- W2887424467 modified "2023-09-26" @default.
- W2887424467 title "Abstract 14446: Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Decreased Elasticity of the Aorta" @default.
- W2887424467 hasPublicationYear "2013" @default.
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