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- W2887431145 abstract "Recent work suggests extensive adaptation of transposable elements (TEs) for host gene regulation. However, high numbers of integrations typical of TEs, coupled with sequence divergence within families, have made systematic interrogation of the regulatory contributions of TEs challenging. Here, we employ CARGO, our recent method for CRISPR gRNA multiplexing, to facilitate targeting of LTR5HS, an ape-specific class of HERVK (HML-2) LTRs that is active during early development and present in ~700 copies throughout the human genome. We combine CARGO with CRISPR activation or interference to, respectively, induce or silence LTR5HS en masse, and demonstrate that this system robustly targets the vast majority of LTR5HS insertions. Remarkably, activation/silencing of LTR5HS is associated with reciprocal up- and down-regulation of hundreds of human genes. These effects require the presence of retroviral sequences, but occur over long genomic distances, consistent with a pervasive function of LTR5HS elements as early embryonic enhancers in apes." @default.
- W2887431145 created "2018-08-22" @default.
- W2887431145 creator A5045133905 @default.
- W2887431145 creator A5058953239 @default.
- W2887431145 creator A5084857406 @default.
- W2887431145 date "2018-08-02" @default.
- W2887431145 modified "2023-09-29" @default.
- W2887431145 title "Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation" @default.
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- W2887431145 doi "https://doi.org/10.7554/elife.35989" @default.