FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887433896> ?p ?o ?g. }

• W2887433896 abstract "Abstract Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms mediating NAFLD pathogenesis are only partially understood. Here we adopt an iterative multi-scale, systems biology approach coupled to in vitro experimentation to investigate the roles of sugar and fat metabolism in NAFLD pathogenesis. The use of fructose as a sweetening agent is controversial; to explore this, we developed a predictive model of human monosaccharide transport, signalling and metabolism. The resulting quantitative model comprising a kinetic model describing monosaccharide transport and insulin signalling integrated with a hepatocyte-specific genome-scale metabolic network (GSMN). Differential kinetics for the utilisation of glucose and fructose were predicted, but the resultant triacylglycerol production was predicted to be similar for monosaccharides; these predictions were verified by in vitro data. The role of physiological adaptation to lipid overload was explored through the comprehensive reconstruction of the peroxisome proliferator activated receptor alpha (PPARα) regulome integrated with a hepatocyte-specific GSMN. The resulting qualitative model reproduced metabolic responses to increased fatty acid levels and mimicked lipid loading in vitro. The model predicted that activation of PPARα by lipids produces a biphasic response, which initially exacerbates steatosis. Our data support the evidence that it is the quantity of sugar rather than the type that is critical in driving the steatotic response. Furthermore, we predict PPARα-mediated adaptations to hepatic lipid overload, shedding light on potential challenges for the use of PPARα agonists to treat NAFLD." @default.
• W2887433896 created "2018-08-22" @default.
• W2887433896 creator A5006098244 @default.
• W2887433896 creator A5008610302 @default.
• W2887433896 creator A5023613170 @default.
• W2887433896 creator A5036949685 @default.
• W2887433896 creator A5051202360 @default.
• W2887433896 creator A5064841800 @default.
• W2887433896 creator A5070101909 @default.
• W2887433896 creator A5071349371 @default.
• W2887433896 date "2018-08-20" @default.
• W2887433896 modified "2023-10-14" @default.
• W2887433896 title "Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease" @default.
• W2887433896 cites W1492485867 @default.
• W2887433896 cites W1863359215 @default.
• W2887433896 cites W1906463904 @default.
• W2887433896 cites W1939763155 @default.
• W2887433896 cites W1965435094 @default.
• W2887433896 cites W1969067437 @default.
• W2887433896 cites W1982920909 @default.
• W2887433896 cites W1983140891 @default.
• W2887433896 cites W1983397628 @default.
• W2887433896 cites W1991153997 @default.
• W2887433896 cites W1997579187 @default.
• W2887433896 cites W2000070179 @default.
• W2887433896 cites W2003250321 @default.
• W2887433896 cites W2023774232 @default.
• W2887433896 cites W2023808897 @default.
• W2887433896 cites W2029431236 @default.
• W2887433896 cites W2040119973 @default.
• W2887433896 cites W2041572943 @default.
• W2887433896 cites W2045278774 @default.
• W2887433896 cites W2045816768 @default.
• W2887433896 cites W2051656202 @default.
• W2887433896 cites W2055736494 @default.
• W2887433896 cites W2067094344 @default.
• W2887433896 cites W2089476104 @default.
• W2887433896 cites W2089881587 @default.
• W2887433896 cites W2102653059 @default.
• W2887433896 cites W2104108767 @default.
• W2887433896 cites W2108195113 @default.
• W2887433896 cites W2108324021 @default.
• W2887433896 cites W2109371472 @default.
• W2887433896 cites W2121509250 @default.
• W2887433896 cites W2126950483 @default.
• W2887433896 cites W2128965269 @default.
• W2887433896 cites W2132218677 @default.
• W2887433896 cites W2143966494 @default.
• W2887433896 cites W2156696514 @default.
• W2887433896 cites W2158497698 @default.
• W2887433896 cites W2163841023 @default.
• W2887433896 cites W2171254281 @default.
• W2887433896 cites W2171697576 @default.
• W2887433896 cites W2236708094 @default.
• W2887433896 cites W2344525015 @default.
• W2887433896 cites W2395375755 @default.
• W2887433896 cites W2405216255 @default.
• W2887433896 cites W2471104923 @default.
• W2887433896 cites W2529551304 @default.
• W2887433896 cites W2550668182 @default.
• W2887433896 cites W2558996269 @default.
• W2887433896 cites W2592185688 @default.
• W2887433896 cites W2612513765 @default.
• W2887433896 cites W2618863496 @default.
• W2887433896 cites W2742474789 @default.
• W2887433896 cites W2755835090 @default.
• W2887433896 cites W2787707131 @default.
• W2887433896 cites W2791251135 @default.
• W2887433896 cites W95898642 @default.
• W2887433896 doi "https://doi.org/10.1038/s41540-018-0070-3" @default.
• W2887433896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6102210" @default.
• W2887433896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30131870" @default.
• W2887433896 hasPublicationYear "2018" @default.
• W2887433896 type Work @default.
• W2887433896 sameAs 2887433896 @default.
• W2887433896 citedByCount "25" @default.
• W2887433896 countsByYear W28874338962019 @default.
• W2887433896 countsByYear W28874338962020 @default.
• W2887433896 countsByYear W28874338962021 @default.
• W2887433896 countsByYear W28874338962022 @default.
• W2887433896 countsByYear W28874338962023 @default.
• W2887433896 crossrefType "journal-article" @default.
• W2887433896 hasAuthorship W2887433896A5006098244 @default.
• W2887433896 hasAuthorship W2887433896A5008610302 @default.
• W2887433896 hasAuthorship W2887433896A5023613170 @default.
• W2887433896 hasAuthorship W2887433896A5036949685 @default.
• W2887433896 hasAuthorship W2887433896A5051202360 @default.
• W2887433896 hasAuthorship W2887433896A5064841800 @default.
• W2887433896 hasAuthorship W2887433896A5070101909 @default.
• W2887433896 hasAuthorship W2887433896A5071349371 @default.
• W2887433896 hasBestOaLocation W28874338961 @default.
• W2887433896 hasConcept C118859902 @default.
• W2887433896 hasConcept C126322002 @default.
• W2887433896 hasConcept C127078168 @default.
• W2887433896 hasConcept C134018914 @default.
• W2887433896 hasConcept C170493617 @default.
• W2887433896 hasConcept C17093226 @default.
• W2887433896 hasConcept C202751555 @default.
• W2887433896 hasConcept C2776175330 @default.
• W2887433896 hasConcept C2776200302 @default.

• next