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- W2887438609 endingPage "3890" @default.
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- W2887438609 abstract "Abstract Next generation biofuels including longer-chain alcohols such as butanol are attractive as renewable, high-energy fuels. A barrier to microbial production of butanols is the increased toxicity compared to ethanol; however, the cellular targets and microbial defense mechanisms remain poorly understood, especially under anaerobic conditions used frequently in industry. Here we took a comparative approach to understand the response of Saccharomyces cerevisiae to 1-butanol, isobutanol, or ethanol, across three genetic backgrounds of varying tolerance in aerobic and anaerobic conditions. We find that strains have different growth properties and alcohol tolerances with and without oxygen availability, as well as unique and common responses to each of the three alcohols. Our results provide evidence for strain-by-alcohol-by-oxygen interactions that moderate how cells respond to alcohol stress." @default.
- W2887438609 created "2018-08-22" @default.
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- W2887438609 creator A5048778946 @default.
- W2887438609 creator A5049047391 @default.
- W2887438609 creator A5064841155 @default.
- W2887438609 date "2018-12-01" @default.
- W2887438609 modified "2023-10-07" @default.
- W2887438609 title "Genotype-by-Environment-by-Environment Interactions in the <i>Saccharomyces cerevisiae</i> Transcriptomic Response to Alcohols and Anaerobiosis" @default.
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- W2887438609 doi "https://doi.org/10.1534/g3.118.200677" @default.
- W2887438609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288825" @default.
- W2887438609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301737" @default.
- W2887438609 hasPublicationYear "2018" @default.
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