FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887441413> ?p ?o ?g. }

• W2887441413 endingPage "448" @default.
• W2887441413 startingPage "430" @default.
• W2887441413 abstract "Protein-Protein Interactions (PPIs) drive major signalling cascades and play critical role in cell proliferation, apoptosis, angiogenesis and trafficking. Deregulated PPIs are implicated in multiple malignancies and represent the critical targets for treating cancer. Herein, we discuss the key protein-protein interacting domains implicated in cancer notably PDZ, SH2, SH3, LIM, PTB, SAM and PH. These domains are present in numerous enzymes/kinases, growth factors, transcription factors, adaptor proteins, receptors and scaffolding proteins and thus represent essential sites for targeting cancer. This review explores the candidature of various proteins involved in cellular trafficking (small GTPases, molecular motors, matrix-degrading enzymes, integrin), transcription (p53, cMyc), signalling (membrane receptor proteins), angiogenesis (VEGFs) and apoptosis (BCL-2family), which could possibly serve as targets for developing effective anti-cancer regimen. Interactions between Ras/Raf; X-linked inhibitor of apoptosis protein (XIAP)/second mitochondria-derived activator of caspases (Smac/DIABLO); Frizzled (FRZ)/Dishevelled (DVL) protein; beta-catenin/T Cell Factor (TCF) have also been studied as prospective anticancer targets. Efficacy of diverse molecules/ drugs targeting such PPIs although evaluated in various animal models/cell lines, there is an essential need for human-based clinical trials. Therapeutic strategies like the use of biologicals, high throughput screening (HTS) and fragment-based technology could play an imperative role in designing cancer therapeutics. Moreover, bioinformatic/computational strategies based on genome sequence, protein sequence/structure and domain data could serve as competent tools for predicting PPIs. Exploring hot spots in proteomic networks represents another approach for developing targetspecific therapeutics. Overall, this review lays emphasis on a productive amalgamation of proteomics, genomics, biochemistry, and molecular dynamics for successful treatment of cancer." @default.
• W2887441413 created "2018-08-22" @default.
• W2887441413 creator A5016133097 @default.
• W2887441413 creator A5024609011 @default.
• W2887441413 creator A5044132707 @default.
• W2887441413 creator A5049358960 @default.
• W2887441413 creator A5053639000 @default.
• W2887441413 creator A5062511556 @default.
• W2887441413 creator A5073951275 @default.
• W2887441413 creator A5090732768 @default.
• W2887441413 date "2019-06-21" @default.
• W2887441413 modified "2023-10-02" @default.
• W2887441413 title "Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View" @default.
• W2887441413 cites W1505632988 @default.
• W2887441413 cites W1953715451 @default.
• W2887441413 cites W1964556094 @default.
• W2887441413 cites W1965819962 @default.
• W2887441413 cites W1965910641 @default.
• W2887441413 cites W1967700176 @default.
• W2887441413 cites W1973345865 @default.
• W2887441413 cites W1975633255 @default.
• W2887441413 cites W1975697981 @default.
• W2887441413 cites W1976353819 @default.
• W2887441413 cites W1976457595 @default.
• W2887441413 cites W1977258127 @default.
• W2887441413 cites W1980480652 @default.
• W2887441413 cites W1981663291 @default.
• W2887441413 cites W1983297180 @default.
• W2887441413 cites W1993591356 @default.
• W2887441413 cites W1995117714 @default.
• W2887441413 cites W1998918148 @default.
• W2887441413 cites W2000970414 @default.
• W2887441413 cites W2003079893 @default.
• W2887441413 cites W2005400237 @default.
• W2887441413 cites W2009158642 @default.
• W2887441413 cites W2010955929 @default.
• W2887441413 cites W2011247549 @default.
• W2887441413 cites W2013414898 @default.
• W2887441413 cites W2014569891 @default.
• W2887441413 cites W2015512041 @default.
• W2887441413 cites W2015809080 @default.
• W2887441413 cites W2015879631 @default.
• W2887441413 cites W2016543925 @default.
• W2887441413 cites W2019241142 @default.
• W2887441413 cites W2023058770 @default.
• W2887441413 cites W2026370952 @default.
• W2887441413 cites W2028387032 @default.
• W2887441413 cites W2030830453 @default.
• W2887441413 cites W2035503835 @default.
• W2887441413 cites W2040576705 @default.
• W2887441413 cites W2041134111 @default.
• W2887441413 cites W2042061022 @default.
• W2887441413 cites W2043750458 @default.
• W2887441413 cites W2045131140 @default.
• W2887441413 cites W2045275149 @default.
• W2887441413 cites W2049463639 @default.
• W2887441413 cites W2051710717 @default.
• W2887441413 cites W2052623429 @default.
• W2887441413 cites W2054434185 @default.
• W2887441413 cites W2055643406 @default.
• W2887441413 cites W2058104225 @default.
• W2887441413 cites W2059274538 @default.
• W2887441413 cites W2059446387 @default.
• W2887441413 cites W2064193818 @default.
• W2887441413 cites W2065802258 @default.
• W2887441413 cites W2066763477 @default.
• W2887441413 cites W2070406942 @default.
• W2887441413 cites W2072435450 @default.
• W2887441413 cites W2075770210 @default.
• W2887441413 cites W2080645234 @default.
• W2887441413 cites W2083906562 @default.
• W2887441413 cites W2085419794 @default.
• W2887441413 cites W2087877138 @default.
• W2887441413 cites W2089355842 @default.
• W2887441413 cites W2099426927 @default.
• W2887441413 cites W2100968572 @default.
• W2887441413 cites W2102601764 @default.
• W2887441413 cites W2105953048 @default.
• W2887441413 cites W2106060578 @default.
• W2887441413 cites W2106096303 @default.
• W2887441413 cites W2106799894 @default.
• W2887441413 cites W2107368531 @default.
• W2887441413 cites W2107424557 @default.
• W2887441413 cites W2109170166 @default.
• W2887441413 cites W2109715166 @default.
• W2887441413 cites W2115001053 @default.
• W2887441413 cites W2117403572 @default.
• W2887441413 cites W2119617160 @default.
• W2887441413 cites W2119780609 @default.
• W2887441413 cites W2121456510 @default.
• W2887441413 cites W2123196322 @default.
• W2887441413 cites W2128900650 @default.
• W2887441413 cites W2133540186 @default.
• W2887441413 cites W2134773861 @default.
• W2887441413 cites W2137465688 @default.
• W2887441413 cites W2145427519 @default.
• W2887441413 cites W2146226667 @default.
• W2887441413 cites W2146312020 @default.

• next