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• W2887451982 abstract "Although obesity and diabetes mellitus, or diabetes, are independently associated with mortality-related events ( e.g., all-cause mortality and cardiovascular-related mortality) following an ischemic stroke, little is known about the joint effect of obesity and diabetes on mortality-related events following an ischemic stroke. The aim of this study is to evaluate the joint effect of obesity and diabetes on mortality-related events in subjects with a recent ischemic stroke. Data from the multicenter Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial was analyzed for this study. The joint effect of obesity and diabetes on mortality-related events was estimated via Cox proportional hazards regression models. No difference in the hazard of all-cause mortality following an ischemic stroke was observed between obese subjects with diabetes and underweight/normal-weight subjects without diabetes. In contrast, obese subjects with diabetes had an increased hazard of cardiovascular-related mortality following an ischemic stroke compared with underweight/normal-weight subjects without diabetes. Additionally, there was evidence of an attributable proportion due to interaction as well as evidence of a highly statistically significant interaction on the multiplicative scale for cardiovascular-related mortality. In this clinical trial cohort of ischemic stroke survivors, obesity and diabetes synergistically interacted to increase the hazard of cardiovascular-related mortality." @default.
• W2887451982 created "2018-08-22" @default.
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• W2887451982 date "2018-08-09" @default.
• W2887451982 modified "2023-10-17" @default.
• W2887451982 title "Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke" @default.
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• W2887451982 doi "https://doi.org/10.1155/2018/4812712" @default.
• W2887451982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6106950" @default.
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• W2887451982 hasPublicationYear "2018" @default.
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