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- W2887461036 abstract "Rationale:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. Objective:The study aimed at identification of molecular mechanisms changing proteasome function in the hypertrophic heart. Method and Results:Proteasome function, expression, and assembly were analyzed during the development of cardiac hypertrophy induced by β-adrenergic stimulation. The analysis revealed, for the first time, divergent regulation of proteasome function in cardiac hypertrophy. Proteasome complexes have 3 different proteolytic activities, which are ATP-dependent for 26S complexes (19S assembled with 20S) and ATP-independent for 20S core particles. The 26S activities were enhanced in hypertrophic hearts, partially because of increased expression and assembly of 19S subunits with 20S co..." @default.
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- W2887461036 date "2010-10-29" @default.
- W2887461036 modified "2023-09-28" @default.
- W2887461036 title "Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy" @default.
- W2887461036 hasPublicationYear "2010" @default.
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