Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887469614> ?p ?o ?g. }
- W2887469614 endingPage "59" @default.
- W2887469614 startingPage "55" @default.
- W2887469614 abstract "Inflammatory bowel disease (IBD) is a group of intestinal non-specific inflammatory diseases with unclear pathogenesis, characterized with the impaired intestinal mucosal barriers and the activated immune system. Mucus layer is the vital protector over the intestinal epithelia cells (IECs). Mucus layer with impaired function could not provide isolated protection for IECs and thus proteases and pathogens from the gut lumen attacked and damaged the epithelial layer. Clinical manifestation and histopathology suggest that IBD might be a self-digestive inflammatory disease caused by digestive enzymes. In this review, we specifically focus on the role of intestinal mucosal barriers and aim to summarize the relationship among mucus layer, self-digestion and inflammation in IBD. We also propose a “Two Hits” Self-Digestion theory to explain the role of self-digestion in IBD and assess the application of mucus protectors to treat IBD." @default.
- W2887469614 created "2018-08-22" @default.
- W2887469614 creator A5002595380 @default.
- W2887469614 creator A5008769293 @default.
- W2887469614 creator A5073531557 @default.
- W2887469614 creator A5075674847 @default.
- W2887469614 creator A5078983945 @default.
- W2887469614 date "2018-11-01" @default.
- W2887469614 modified "2023-09-26" @default.
- W2887469614 title "Mucus protectors: Promising therapeutic strategies for inflammatory bowel disease" @default.
- W2887469614 cites W1494525664 @default.
- W2887469614 cites W1590241359 @default.
- W2887469614 cites W1964493018 @default.
- W2887469614 cites W1967217097 @default.
- W2887469614 cites W1967908165 @default.
- W2887469614 cites W1974259421 @default.
- W2887469614 cites W1987650422 @default.
- W2887469614 cites W2005894594 @default.
- W2887469614 cites W2006219049 @default.
- W2887469614 cites W2011337131 @default.
- W2887469614 cites W2011529702 @default.
- W2887469614 cites W2020344279 @default.
- W2887469614 cites W2030751091 @default.
- W2887469614 cites W2031558979 @default.
- W2887469614 cites W2031735410 @default.
- W2887469614 cites W2035974720 @default.
- W2887469614 cites W2046834487 @default.
- W2887469614 cites W2049771483 @default.
- W2887469614 cites W2054642708 @default.
- W2887469614 cites W2065903707 @default.
- W2887469614 cites W2067610112 @default.
- W2887469614 cites W2080466925 @default.
- W2887469614 cites W2085240670 @default.
- W2887469614 cites W2088192427 @default.
- W2887469614 cites W2102949149 @default.
- W2887469614 cites W2104992254 @default.
- W2887469614 cites W2106779017 @default.
- W2887469614 cites W2113474033 @default.
- W2887469614 cites W2122292170 @default.
- W2887469614 cites W2125092417 @default.
- W2887469614 cites W2126131092 @default.
- W2887469614 cites W2132122176 @default.
- W2887469614 cites W2138597790 @default.
- W2887469614 cites W2151872119 @default.
- W2887469614 cites W2159833823 @default.
- W2887469614 cites W2172343413 @default.
- W2887469614 cites W2209314464 @default.
- W2887469614 cites W2405188649 @default.
- W2887469614 cites W2472937029 @default.
- W2887469614 cites W2559505350 @default.
- W2887469614 cites W2577331563 @default.
- W2887469614 cites W2602001549 @default.
- W2887469614 cites W2740128812 @default.
- W2887469614 cites W2782413694 @default.
- W2887469614 doi "https://doi.org/10.1016/j.mehy.2018.08.013" @default.
- W2887469614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30220341" @default.
- W2887469614 hasPublicationYear "2018" @default.
- W2887469614 type Work @default.
- W2887469614 sameAs 2887469614 @default.
- W2887469614 citedByCount "3" @default.
- W2887469614 countsByYear W28874696142020 @default.
- W2887469614 countsByYear W28874696142021 @default.
- W2887469614 countsByYear W28874696142022 @default.
- W2887469614 crossrefType "journal-article" @default.
- W2887469614 hasAuthorship W2887469614A5002595380 @default.
- W2887469614 hasAuthorship W2887469614A5008769293 @default.
- W2887469614 hasAuthorship W2887469614A5073531557 @default.
- W2887469614 hasAuthorship W2887469614A5075674847 @default.
- W2887469614 hasAuthorship W2887469614A5078983945 @default.
- W2887469614 hasConcept C126322002 @default.
- W2887469614 hasConcept C142724271 @default.
- W2887469614 hasConcept C181199279 @default.
- W2887469614 hasConcept C182220744 @default.
- W2887469614 hasConcept C185592680 @default.
- W2887469614 hasConcept C18903297 @default.
- W2887469614 hasConcept C203014093 @default.
- W2887469614 hasConcept C2776914184 @default.
- W2887469614 hasConcept C2777312293 @default.
- W2887469614 hasConcept C2778260677 @default.
- W2887469614 hasConcept C2779134260 @default.
- W2887469614 hasConcept C2780942790 @default.
- W2887469614 hasConcept C2781357212 @default.
- W2887469614 hasConcept C3019368612 @default.
- W2887469614 hasConcept C43617362 @default.
- W2887469614 hasConcept C55493867 @default.
- W2887469614 hasConcept C71924100 @default.
- W2887469614 hasConcept C86803240 @default.
- W2887469614 hasConcept C8891405 @default.
- W2887469614 hasConceptScore W2887469614C126322002 @default.
- W2887469614 hasConceptScore W2887469614C142724271 @default.
- W2887469614 hasConceptScore W2887469614C181199279 @default.
- W2887469614 hasConceptScore W2887469614C182220744 @default.
- W2887469614 hasConceptScore W2887469614C185592680 @default.
- W2887469614 hasConceptScore W2887469614C18903297 @default.
- W2887469614 hasConceptScore W2887469614C203014093 @default.
- W2887469614 hasConceptScore W2887469614C2776914184 @default.
- W2887469614 hasConceptScore W2887469614C2777312293 @default.
- W2887469614 hasConceptScore W2887469614C2778260677 @default.