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- W2887479944 abstract "The importance of vascular endothelial growth factor in (VEGF) thepathogenesis of diabetic retinopathy is evident from numerous studies demonstrating asignificant increase in VEGF levels in ocular samples. However, a correlation between bloodlevels of VEGF and diabetic retinopathy has not been conclusively proven or disproven. Weundertake this study to demonstrate the relationship between blood levels of VEGF and theseverity of diabetic retinopathy.METHODS: The study population consisted of 75 Type 2 diabetic patients attending ouroutpatient department for routine diabetic retinopathy screening. After obtaining informedconsent, 5ml of blood was drawn from each patient and estimated for the levels of serumVEGF. The data thus obtained was correlated with the grade of retinopathy. Additionalparameters studied were duration of diabetes, haemoglobin levels, blood urea, serumcreatinine, fasting and random blood sugars and HBA1C levels.RESULTS: There was a significant elevation of blood VEGF levels when compared to thenormal population. But this elevation was seen in all the patients irrespective of whether theyhad retinopathy or not. There was no correlation detected between VEGF levels and theseverity of diabetes. There was a positive association between anemia and the severity ofretinopathy. The levels of urea and creatinine were elevated in the more severe grade ofretinopathy. There was an overall poor control of sugars reflected both by the high levels offasting and random sugars and the high HBA1C.CONCLUSION: Levels of blood VEGF are elevated in diabetic patients regardless ofwhether they have diabetic retinopathy or not. There is no statistically significant relationshipbetween blood levels of VEGF and the severity of retinopathy. VEGF, therefore couldpresent a potential treatment and preventive strategy for not only diabetic retinopathy butdiabetes and its complications in general." @default.
- W2887479944 created "2018-08-22" @default.
- W2887479944 creator A5087393726 @default.
- W2887479944 date "2016-04-01" @default.
- W2887479944 modified "2023-09-27" @default.
- W2887479944 title "A study on the relationship between blood levels of vascular endothelial growth factor and severity of diabetic retinopathy" @default.
- W2887479944 hasPublicationYear "2016" @default.
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