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• W2887487741 abstract "The hydrophilic extracts of mulberry (HEM) and blueberry (HEB) and lipophilic extracts of mango (LEM) and watermelon (LEW) were mixed in different ratios to assess the antioxidant interactions by chemical-based (DPPH and ABTS assays) and H9c2 cell-based models. There were both synergistic and antagonistic antioxidant interactions among these fruits. Some groups with combinational extracts showed stronger synergistic antioxidant effects than the individual groups, and others (HEM–LEW F1/10, LEW–LEM F5/10, and HEB–LEM F3/10) showed stronger antagonistic effects than the individual groups based on the indicators [the values of DPPH, ABTS, and MTT; the expression of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA); the release of lactate dehydrogenase (LDH); and the quantification of cellular antioxidant activity]. The principal component analysis (PCA) showed that samples could be defined by two principal components: PC1, the main phenolic acids and anthocyanins, and PC2, carotenoids. From our results, primarily, carotenoids were in the majority in antagonistic groups, and phenolics and anthocyanins were in the majority in synergistic groups. However, the combinational groups containing only hydrophilic compounds did not always show synergistic effects. Therefore, the compatibility of diets indicates balancing the ratios of hydrophilic and lipophlic compounds in our daily food. In addition, the expression of enzymes (SOD, GSH-Px, and CAT) may not be sensitive to the changes of antioxidant activity caused by the combinations with different ratios of hydrophilic and lipophilc compounds. The different structures of lipophilic compounds (β-carotene and lycopene) could influence the antagonistic effects." @default.
• W2887487741 created "2018-08-22" @default.
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• W2887487741 date "2018-08-07" @default.
• W2887487741 modified "2023-10-14" @default.
• W2887487741 title "Daily Dietary Antioxidant Interactions Are Due to Not Only the Quantity but Also the Ratios of Hydrophilic and Lipophilic Phytochemicals" @default.
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• W2887487741 doi "https://doi.org/10.1021/acs.jafc.8b03412" @default.
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• W2887487741 hasPublicationYear "2018" @default.
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