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- W2887490149 abstract "During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Rap2 GTPase (rap-2) and its effector, TNIK (mig-15), act genetically downstream of Plexin (plx-1) to restrict presynaptic assembly and to form tiled synaptic innervation in C. elegans. Both constitutively GTP- and GDP-forms of rap-2 mutants exhibit synaptic tiling defects as plx-1 mutants, suggesting that cycling of the RAP-2 nucleotide state is critical for synapse inhibition. Consistently, PLX-1 suppresses local RAP-2 activity. Excessive ectopic synapse formation in mig-15 mutants causes a severe synaptic tiling defect. Conversely, overexpression of mig-15 strongly inhibited synapse formation, suggesting that mig-15 is a negative regulator of synapse formation. These results reveal that subcellular regulation of small GTPase activity by Plexin shapes proper synapse patterning in vivo." @default.
- W2887490149 created "2018-08-22" @default.
- W2887490149 creator A5008171524 @default.
- W2887490149 creator A5030192413 @default.
- W2887490149 creator A5037281571 @default.
- W2887490149 creator A5042667110 @default.
- W2887490149 creator A5044867191 @default.
- W2887490149 creator A5052894411 @default.
- W2887490149 creator A5055620335 @default.
- W2887490149 creator A5073505034 @default.
- W2887490149 creator A5082587033 @default.
- W2887490149 date "2018-07-31" @default.
- W2887490149 modified "2023-10-13" @default.
- W2887490149 title "Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans" @default.
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