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- W2887492487 abstract "Abstract Mice homozygous for the Y208N amino acid substitution in the carboxy terminus of SHP-1 (referred to as Ptpn6spin mice) spontaneously develop a severe inflammatory disease resembling neutrophilic dermatosis in humans. Disease in Ptpn6spin mice is characterized by persistent footpad swelling and suppurative inflammation. Recently, in addition to IL-1α and IL-1R signaling, we demonstrated a pivotal role for RIPK1, TAK1, and ASK1 in promoting inflammatory disease in Ptpn6spin mice. In the current study we have identified a previously unknown role for CARD9 signaling as a critical regulator for Ptpn6spin-mediated footpad inflammation. Genetic deletion of CARD9 significantly rescued the Ptpn6spin-mediated footpad inflammation. Mechanistically, enhanced IL-1α–mediated signaling in Ptpn6spin mice neutrophils was dampened in Ptpn6spinCard9−/− mice. Collectively, this study identifies SHP-1 and CARD9 cross-talk as a novel regulator of IL-1α–driven inflammation and opens future avenues for finding novel drug targets to treat neutrophilic dermatosis in humans." @default.
- W2887492487 created "2018-08-22" @default.
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- W2887492487 date "2018-09-15" @default.
- W2887492487 modified "2023-10-11" @default.
- W2887492487 title "Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses" @default.
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- W2887492487 doi "https://doi.org/10.4049/jimmunol.1800760" @default.
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