Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887510462> ?p ?o ?g. }
- W2887510462 endingPage "185" @default.
- W2887510462 startingPage "177" @default.
- W2887510462 abstract "Ischemic stroke causes endothelial dysfunction and blood–brain barrier dysfunction, thus damages synaptic plasticity such as learning and memory. In this study we aim to investigate the effect of hemopexin (HPX) in protecting synaptic plasticity and blood brain barrier integrity from toxic heme, and determine whether this effect is via the activation of endothelial progenitor cells (EPCs) through the heme oxygenase-1 (HO-1) pathway. Our data indicates HPX showed a significant effect in inducing the expression of HO-1, promoting the migration and differentiation of EPCs, facilitating new blood vessel formation thus protecting blood–brain barrier integrity. Also the magnitude of synaptic plasticity of rats recovered with HPX treatment. And in the presence of HO-1 blocker Zinc protoporphyrin-9 (ZnppIX), HPX lost its protective effect. This suggests that HPX protects endothelial and blood brain barrier integrity from toxic heme, thus protects neurologic function in cerebral ischemic rats in HO-1 pathway." @default.
- W2887510462 created "2018-08-22" @default.
- W2887510462 creator A5010929663 @default.
- W2887510462 creator A5034382078 @default.
- W2887510462 creator A5045810332 @default.
- W2887510462 creator A5073871300 @default.
- W2887510462 creator A5076005978 @default.
- W2887510462 date "2018-11-01" @default.
- W2887510462 modified "2023-09-23" @default.
- W2887510462 title "Hemopexin reduces blood–brain barrier injury and protects synaptic plasticity in cerebral ischemic rats by promoting EPCs through the HO-1 pathway" @default.
- W2887510462 cites W1557671060 @default.
- W2887510462 cites W1772958444 @default.
- W2887510462 cites W1937781734 @default.
- W2887510462 cites W1973648711 @default.
- W2887510462 cites W1994428975 @default.
- W2887510462 cites W2003548151 @default.
- W2887510462 cites W2029588112 @default.
- W2887510462 cites W2037821795 @default.
- W2887510462 cites W2040591047 @default.
- W2887510462 cites W2047363331 @default.
- W2887510462 cites W2049406282 @default.
- W2887510462 cites W2069225082 @default.
- W2887510462 cites W2095263989 @default.
- W2887510462 cites W2101790526 @default.
- W2887510462 cites W2107922629 @default.
- W2887510462 cites W2162189519 @default.
- W2887510462 cites W2268084917 @default.
- W2887510462 cites W2331505172 @default.
- W2887510462 cites W2345400600 @default.
- W2887510462 cites W2399676695 @default.
- W2887510462 cites W2517744753 @default.
- W2887510462 cites W2569441574 @default.
- W2887510462 cites W2587558518 @default.
- W2887510462 cites W2590500739 @default.
- W2887510462 cites W2591104912 @default.
- W2887510462 cites W2605863465 @default.
- W2887510462 cites W2611113257 @default.
- W2887510462 cites W2733966599 @default.
- W2887510462 cites W2786608785 @default.
- W2887510462 cites W2791041386 @default.
- W2887510462 cites W640853832 @default.
- W2887510462 doi "https://doi.org/10.1016/j.brainres.2018.08.008" @default.
- W2887510462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30092232" @default.
- W2887510462 hasPublicationYear "2018" @default.
- W2887510462 type Work @default.
- W2887510462 sameAs 2887510462 @default.
- W2887510462 citedByCount "18" @default.
- W2887510462 countsByYear W28875104622019 @default.
- W2887510462 countsByYear W28875104622020 @default.
- W2887510462 countsByYear W28875104622021 @default.
- W2887510462 countsByYear W28875104622022 @default.
- W2887510462 countsByYear W28875104622023 @default.
- W2887510462 crossrefType "journal-article" @default.
- W2887510462 hasAuthorship W2887510462A5010929663 @default.
- W2887510462 hasAuthorship W2887510462A5034382078 @default.
- W2887510462 hasAuthorship W2887510462A5045810332 @default.
- W2887510462 hasAuthorship W2887510462A5073871300 @default.
- W2887510462 hasAuthorship W2887510462A5076005978 @default.
- W2887510462 hasConcept C126322002 @default.
- W2887510462 hasConcept C169760540 @default.
- W2887510462 hasConcept C170493617 @default.
- W2887510462 hasConcept C181199279 @default.
- W2887510462 hasConcept C201750760 @default.
- W2887510462 hasConcept C2776217839 @default.
- W2887510462 hasConcept C2776474381 @default.
- W2887510462 hasConcept C2778402981 @default.
- W2887510462 hasConcept C2779219270 @default.
- W2887510462 hasConcept C28328180 @default.
- W2887510462 hasConcept C529278444 @default.
- W2887510462 hasConcept C55493867 @default.
- W2887510462 hasConcept C71924100 @default.
- W2887510462 hasConcept C86803240 @default.
- W2887510462 hasConcept C95444343 @default.
- W2887510462 hasConcept C98229152 @default.
- W2887510462 hasConceptScore W2887510462C126322002 @default.
- W2887510462 hasConceptScore W2887510462C169760540 @default.
- W2887510462 hasConceptScore W2887510462C170493617 @default.
- W2887510462 hasConceptScore W2887510462C181199279 @default.
- W2887510462 hasConceptScore W2887510462C201750760 @default.
- W2887510462 hasConceptScore W2887510462C2776217839 @default.
- W2887510462 hasConceptScore W2887510462C2776474381 @default.
- W2887510462 hasConceptScore W2887510462C2778402981 @default.
- W2887510462 hasConceptScore W2887510462C2779219270 @default.
- W2887510462 hasConceptScore W2887510462C28328180 @default.
- W2887510462 hasConceptScore W2887510462C529278444 @default.
- W2887510462 hasConceptScore W2887510462C55493867 @default.
- W2887510462 hasConceptScore W2887510462C71924100 @default.
- W2887510462 hasConceptScore W2887510462C86803240 @default.
- W2887510462 hasConceptScore W2887510462C95444343 @default.
- W2887510462 hasConceptScore W2887510462C98229152 @default.
- W2887510462 hasFunder F4320321001 @default.
- W2887510462 hasFunder F4320326234 @default.
- W2887510462 hasLocation W28875104621 @default.
- W2887510462 hasLocation W28875104622 @default.
- W2887510462 hasOpenAccess W2887510462 @default.
- W2887510462 hasPrimaryLocation W28875104621 @default.
- W2887510462 hasRelatedWork W1573477258 @default.
- W2887510462 hasRelatedWork W1631638135 @default.