Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887528073> ?p ?o ?g. }
- W2887528073 abstract "Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Gria1-/- mice exhibit a phenotype relevant for neuropsychiatric disorders, including reduced synaptic plasticity and, at the behavioural level, attentional deficits leading to aberrant salience. In this study we report a striking reduction of EEG power density including the spindle-frequency range (10-15 Hz) during sleep in Gria1-/- mice. The reduction of spindle-activity in Gria1-/- mice was accompanied by longer REM sleep episodes, increased EEG slow-wave activity in the occipital derivation during baseline sleep, and a reduced rate of decline of EEG slow wave activity (0.5-4 Hz) during NREM sleep after sleep deprivation. These data provide a novel link between glutamatergic dysfunction and sleep abnormalities in a schizophrenia-relevant mouse model." @default.
- W2887528073 created "2018-08-22" @default.
- W2887528073 creator A5005383467 @default.
- W2887528073 creator A5009326571 @default.
- W2887528073 creator A5009783365 @default.
- W2887528073 creator A5032247114 @default.
- W2887528073 creator A5041981916 @default.
- W2887528073 creator A5043264733 @default.
- W2887528073 creator A5048391309 @default.
- W2887528073 creator A5050681797 @default.
- W2887528073 creator A5052700816 @default.
- W2887528073 creator A5053168396 @default.
- W2887528073 creator A5061367170 @default.
- W2887528073 creator A5067384437 @default.
- W2887528073 date "2018-08-14" @default.
- W2887528073 modified "2023-10-14" @default.
- W2887528073 title "Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders" @default.
- W2887528073 cites W1510072837 @default.
- W2887528073 cites W15209316 @default.
- W2887528073 cites W1534720449 @default.
- W2887528073 cites W1841190780 @default.
- W2887528073 cites W1884361550 @default.
- W2887528073 cites W1907939914 @default.
- W2887528073 cites W1952601298 @default.
- W2887528073 cites W1956450144 @default.
- W2887528073 cites W1965589268 @default.
- W2887528073 cites W1968790919 @default.
- W2887528073 cites W1972145246 @default.
- W2887528073 cites W1972852256 @default.
- W2887528073 cites W1973117088 @default.
- W2887528073 cites W1973294321 @default.
- W2887528073 cites W1973848754 @default.
- W2887528073 cites W1975851634 @default.
- W2887528073 cites W1978417991 @default.
- W2887528073 cites W1979897030 @default.
- W2887528073 cites W1980288648 @default.
- W2887528073 cites W1992225639 @default.
- W2887528073 cites W1992232671 @default.
- W2887528073 cites W1993782477 @default.
- W2887528073 cites W1994083272 @default.
- W2887528073 cites W1994341292 @default.
- W2887528073 cites W1995200202 @default.
- W2887528073 cites W1997680764 @default.
- W2887528073 cites W1999595923 @default.
- W2887528073 cites W2001441661 @default.
- W2887528073 cites W2004454719 @default.
- W2887528073 cites W2006955019 @default.
- W2887528073 cites W2011678579 @default.
- W2887528073 cites W2018279223 @default.
- W2887528073 cites W2018329664 @default.
- W2887528073 cites W2019559257 @default.
- W2887528073 cites W2028054573 @default.
- W2887528073 cites W2030409995 @default.
- W2887528073 cites W2035054118 @default.
- W2887528073 cites W2036803444 @default.
- W2887528073 cites W2037015499 @default.
- W2887528073 cites W2042317394 @default.
- W2887528073 cites W2043547634 @default.
- W2887528073 cites W2045125289 @default.
- W2887528073 cites W2047607120 @default.
- W2887528073 cites W2048135478 @default.
- W2887528073 cites W2052014603 @default.
- W2887528073 cites W2052324242 @default.
- W2887528073 cites W2053342542 @default.
- W2887528073 cites W2058387509 @default.
- W2887528073 cites W2061234946 @default.
- W2887528073 cites W2064155672 @default.
- W2887528073 cites W2066252334 @default.
- W2887528073 cites W2066774437 @default.
- W2887528073 cites W2071151408 @default.
- W2887528073 cites W2077633827 @default.
- W2887528073 cites W2078748724 @default.
- W2887528073 cites W2080350938 @default.
- W2887528073 cites W2082699503 @default.
- W2887528073 cites W2088046534 @default.
- W2887528073 cites W2090315560 @default.
- W2887528073 cites W2093248761 @default.
- W2887528073 cites W2095475551 @default.
- W2887528073 cites W2097639486 @default.
- W2887528073 cites W2101059856 @default.
- W2887528073 cites W2101357408 @default.
- W2887528073 cites W2102656701 @default.
- W2887528073 cites W2103230563 @default.
- W2887528073 cites W2111911706 @default.
- W2887528073 cites W2121407089 @default.
- W2887528073 cites W2128942012 @default.
- W2887528073 cites W2128964866 @default.
- W2887528073 cites W2130784302 @default.
- W2887528073 cites W2131436025 @default.
- W2887528073 cites W2132159591 @default.
- W2887528073 cites W2135212205 @default.
- W2887528073 cites W2138560354 @default.
- W2887528073 cites W2143867600 @default.
- W2887528073 cites W2147259071 @default.
- W2887528073 cites W2151654262 @default.
- W2887528073 cites W2157964542 @default.
- W2887528073 cites W2160512736 @default.
- W2887528073 cites W2170621766 @default.
- W2887528073 cites W2218418953 @default.
- W2887528073 cites W2261519444 @default.