FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887533110> ?p ?o ?g. }

• W2887533110 endingPage "2493" @default.
• W2887533110 startingPage "2481" @default.
• W2887533110 abstract "Flightless I (FliI) is a calcium-dependent, actin severing and capping protein that localizes to cell matrix adhesions, contributes to the generation of cell extensions, and colocalizes with Ras. Currently, the mechanism by which FliI interacts with Ras to enable assembly of actin-based cell protrusions is not defined. R-Ras, but not K-ras, H-ras, or N-ras, associated with the leucine-rich region (LRR) of FliI. Mutations of the proline-rich region of R-ras (P202A, P203A) prevented this association. Knockdown of Ras GTPase-activating SH3 domain-binding protein (G3BP1) or Rasgap 120 by small interfering RNA inhibited the formation of cell extensions and prevented interaction of R-ras and G3BP1 in FliI wild-type (WT) cells. Pull-down assays using G3BP1 fusion proteins showed a strong association of R-ras with the C-terminus of G3BP1 (amino acids 236–466), which also required the LRR of FliI. In cells that expressed the truncated N-terminus or C-terminus of G3BP1, the formation of cell extensions was blocked. Endogenous Rasgap 120 interacted with the N-terminus of G3BP1 (amino acids 1–230). We conclude that in cells plated on collagen FliI-LRR interacts with R-ras to promote cell extension formation and that FliI is required for the interaction of Rasgap 120 with G3BP1 to regulate R-ras activity and growth of cell extensions." @default.
• W2887533110 created "2018-08-22" @default.
• W2887533110 creator A5019267367 @default.
• W2887533110 creator A5043518753 @default.
• W2887533110 creator A5051002562 @default.
• W2887533110 creator A5090169205 @default.
• W2887533110 date "2018-10-01" @default.
• W2887533110 modified "2023-09-25" @default.
• W2887533110 title "The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation" @default.
• W2887533110 cites W1508263702 @default.
• W2887533110 cites W1521115629 @default.
• W2887533110 cites W1753843006 @default.
• W2887533110 cites W1820462433 @default.
• W2887533110 cites W1823558083 @default.
• W2887533110 cites W1867305038 @default.
• W2887533110 cites W1925705209 @default.
• W2887533110 cites W1965498876 @default.
• W2887533110 cites W1966254272 @default.
• W2887533110 cites W1967007710 @default.
• W2887533110 cites W1971105753 @default.
• W2887533110 cites W1979517563 @default.
• W2887533110 cites W1981045929 @default.
• W2887533110 cites W1982021133 @default.
• W2887533110 cites W1984896714 @default.
• W2887533110 cites W1990995529 @default.
• W2887533110 cites W1993735775 @default.
• W2887533110 cites W1994811935 @default.
• W2887533110 cites W2008422889 @default.
• W2887533110 cites W2017197065 @default.
• W2887533110 cites W2018924043 @default.
• W2887533110 cites W2024095146 @default.
• W2887533110 cites W2027113655 @default.
• W2887533110 cites W2030422302 @default.
• W2887533110 cites W2033949902 @default.
• W2887533110 cites W2041025244 @default.
• W2887533110 cites W2055873134 @default.
• W2887533110 cites W2068881539 @default.
• W2887533110 cites W2069738597 @default.
• W2887533110 cites W2072371497 @default.
• W2887533110 cites W2077256089 @default.
• W2887533110 cites W2086607694 @default.
• W2887533110 cites W2090778735 @default.
• W2887533110 cites W2090842150 @default.
• W2887533110 cites W2098514810 @default.
• W2887533110 cites W2117911065 @default.
• W2887533110 cites W2124696767 @default.
• W2887533110 cites W2131779930 @default.
• W2887533110 cites W2139294293 @default.
• W2887533110 cites W2144357409 @default.
• W2887533110 cites W2146645867 @default.
• W2887533110 cites W2153438387 @default.
• W2887533110 cites W2258555286 @default.
• W2887533110 cites W2329321343 @default.
• W2887533110 cites W2614109783 @default.
• W2887533110 cites W59378509 @default.
• W2887533110 doi "https://doi.org/10.1091/mbc.e18-03-0147" @default.
• W2887533110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6233052" @default.
• W2887533110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30091651" @default.
• W2887533110 hasPublicationYear "2018" @default.
• W2887533110 type Work @default.
• W2887533110 sameAs 2887533110 @default.
• W2887533110 citedByCount "6" @default.
• W2887533110 countsByYear W28875331102018 @default.
• W2887533110 countsByYear W28875331102020 @default.
• W2887533110 countsByYear W28875331102021 @default.
• W2887533110 countsByYear W28875331102023 @default.
• W2887533110 crossrefType "journal-article" @default.
• W2887533110 hasAuthorship W2887533110A5019267367 @default.
• W2887533110 hasAuthorship W2887533110A5043518753 @default.
• W2887533110 hasAuthorship W2887533110A5051002562 @default.
• W2887533110 hasAuthorship W2887533110A5090169205 @default.
• W2887533110 hasBestOaLocation W28875331101 @default.
• W2887533110 hasConcept C108636557 @default.
• W2887533110 hasConcept C1491633281 @default.
• W2887533110 hasConcept C163181125 @default.
• W2887533110 hasConcept C173396325 @default.
• W2887533110 hasConcept C196347352 @default.
• W2887533110 hasConcept C207332259 @default.
• W2887533110 hasConcept C2780040266 @default.
• W2887533110 hasConcept C54355233 @default.
• W2887533110 hasConcept C55493867 @default.
• W2887533110 hasConcept C62112901 @default.
• W2887533110 hasConcept C62478195 @default.
• W2887533110 hasConcept C80631254 @default.
• W2887533110 hasConcept C81885089 @default.
• W2887533110 hasConcept C86803240 @default.
• W2887533110 hasConcept C95444343 @default.
• W2887533110 hasConceptScore W2887533110C108636557 @default.
• W2887533110 hasConceptScore W2887533110C1491633281 @default.
• W2887533110 hasConceptScore W2887533110C163181125 @default.
• W2887533110 hasConceptScore W2887533110C173396325 @default.
• W2887533110 hasConceptScore W2887533110C196347352 @default.
• W2887533110 hasConceptScore W2887533110C207332259 @default.
• W2887533110 hasConceptScore W2887533110C2780040266 @default.
• W2887533110 hasConceptScore W2887533110C54355233 @default.
• W2887533110 hasConceptScore W2887533110C55493867 @default.
• W2887533110 hasConceptScore W2887533110C62112901 @default.
• W2887533110 hasConceptScore W2887533110C62478195 @default.

• next