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- W2887559575 abstract "Abstract Introduction To extend the knowledge base about possible prevalence declines of specific orofacial cleft phenotypes, here we examine prevalence in a population base from California over a two‐decade period among numerous race/ethnic groups. Methods This population‐based study used vital statistics and birth defects registry data. Its population involved all births (~1.5 million births) in central California counties from 1987 to 2010. Orofacial clefts were defined as cleft lip with or without cleft palate (CLP, n=1766), and cleft palate (CP, n=922) only. The slope of prevalence of each cleft phenotype over the period 1987‐2010 was estimated using weighted least squares regression. Results Birth prevalence of CLP was 121/100,000 live births, and 63/100,000 live births for CP. The slope for CLP decreased by 1.2 (slope: ‐1.2; 95% CI: ‐1.9, ‐0.5), and for CP by 0.7 (slope: ‐0.7; 95% CI: ‐1.7, 0.2) for CP. Stratification by race/ethnicity or infant sex did not demonstrate a statistical difference in slopes. Conclusions We observed a decline in the prevalence in CLP in all ethnic groups, however did not observe the same amount of decline in CP, perhaps due to antenatal screening." @default.
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- W2887559575 date "2018-07-31" @default.
- W2887559575 modified "2023-10-16" @default.
- W2887559575 title "Change in Prevalence of Orofacial Clefts in California between 1987 and 2010" @default.
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- W2887559575 doi "https://doi.org/10.1002/ajmg.a.40384" @default.
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