Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887568085> ?p ?o ?g. }
- W2887568085 abstract "Clostridium difficile infection (CDI) is a spore-forming anaerobic bacterium and leading cause of antibiotic-associated colitis. Epidemiological data suggest that use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk for CDI in humans, a potentially important observation given the widespread use of NSAIDs. Prior studies in rodent models of CDI found that NSAID exposure following infection increases the severity of CDI, but mechanisms to explain this are lacking. Here we present new data from a mouse model of antibiotic-associated CDI suggesting that brief NSAID exposure prior to CDI increases the severity of the infectious colitis. These data shed new light on potential mechanisms linking NSAID use to worsened CDI, including drug-induced disturbances to the gut microbiome and colonic epithelial integrity. Studies were limited to a single NSAID (indomethacin), so future studies are needed to assess the generalizability of our findings and to establish a direct link to the human condition." @default.
- W2887568085 created "2018-08-22" @default.
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- W2887568085 creator A5087826096 @default.
- W2887568085 date "2019-02-26" @default.
- W2887568085 modified "2023-10-10" @default.
- W2887568085 title "Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate <i>Clostridium difficile</i> Colitis while Dysregulating the Inflammatory Response" @default.
- W2887568085 cites W1163643844 @default.
- W2887568085 cites W1490158929 @default.
- W2887568085 cites W1583343932 @default.
- W2887568085 cites W1836263069 @default.
- W2887568085 cites W1896600727 @default.
- W2887568085 cites W1907898035 @default.
- W2887568085 cites W1913844335 @default.
- W2887568085 cites W1943350258 @default.
- W2887568085 cites W1953168141 @default.
- W2887568085 cites W1963308907 @default.
- W2887568085 cites W1965629335 @default.
- W2887568085 cites W1968719631 @default.
- W2887568085 cites W1971497070 @default.
- W2887568085 cites W1971575021 @default.
- W2887568085 cites W1972603985 @default.
- W2887568085 cites W1973650764 @default.
- W2887568085 cites W1977761329 @default.
- W2887568085 cites W1983754832 @default.
- W2887568085 cites W1986684675 @default.
- W2887568085 cites W1988564036 @default.
- W2887568085 cites W2011927695 @default.
- W2887568085 cites W2021632992 @default.
- W2887568085 cites W2027039192 @default.
- W2887568085 cites W2038094516 @default.
- W2887568085 cites W2041040328 @default.
- W2887568085 cites W2043460853 @default.
- W2887568085 cites W2049355215 @default.
- W2887568085 cites W2052017014 @default.
- W2887568085 cites W2054164832 @default.
- W2887568085 cites W2071054182 @default.
- W2887568085 cites W2076986757 @default.
- W2887568085 cites W2078957915 @default.
- W2887568085 cites W2080289362 @default.
- W2887568085 cites W2081653606 @default.
- W2887568085 cites W2081820575 @default.
- W2887568085 cites W2083803409 @default.
- W2887568085 cites W2085099489 @default.
- W2887568085 cites W2094041617 @default.
- W2887568085 cites W2099266276 @default.
- W2887568085 cites W2102526590 @default.
- W2887568085 cites W2108718991 @default.
- W2887568085 cites W2110147288 @default.
- W2887568085 cites W2117457769 @default.
- W2887568085 cites W2130594874 @default.
- W2887568085 cites W2133856765 @default.
- W2887568085 cites W2135717147 @default.
- W2887568085 cites W2135959117 @default.
- W2887568085 cites W2137104765 @default.
- W2887568085 cites W2138492548 @default.
- W2887568085 cites W2138818997 @default.
- W2887568085 cites W2141368172 @default.
- W2887568085 cites W2142613038 @default.
- W2887568085 cites W2143154387 @default.
- W2887568085 cites W2144974013 @default.
- W2887568085 cites W2145356341 @default.
- W2887568085 cites W2149696605 @default.
- W2887568085 cites W2149711482 @default.
- W2887568085 cites W2156890871 @default.
- W2887568085 cites W2159447128 @default.
- W2887568085 cites W2165257283 @default.
- W2887568085 cites W2177687538 @default.
- W2887568085 cites W2287745926 @default.
- W2887568085 cites W2302497041 @default.
- W2887568085 cites W2310510539 @default.
- W2887568085 cites W2381299150 @default.
- W2887568085 cites W2398390426 @default.
- W2887568085 cites W2461637653 @default.
- W2887568085 cites W2507523231 @default.
- W2887568085 cites W2511494454 @default.
- W2887568085 cites W2514686933 @default.
- W2887568085 cites W2522105518 @default.
- W2887568085 cites W2525178139 @default.
- W2887568085 cites W2529692498 @default.
- W2887568085 cites W2530003151 @default.
- W2887568085 cites W2535078809 @default.
- W2887568085 cites W2570860549 @default.
- W2887568085 cites W2578482213 @default.
- W2887568085 cites W2580031513 @default.
- W2887568085 cites W2586959160 @default.
- W2887568085 cites W2609398719 @default.