Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887569257> ?p ?o ?g. }
- W2887569257 endingPage "947" @default.
- W2887569257 startingPage "938" @default.
- W2887569257 abstract "Bacterial type 4 pili (T4P) are extracellular polymers that initiate the formation of microcolonies and biofilms. T4P continuously elongate and retract. These pilus dynamics crucially affect the local order, shape, and fluidity of microcolonies. The major pilin subunit of the T4P bears multiple post-translational modifications. By interfering with different steps of the pilin glycosylation and phosphoform modification pathways, we investigated the effect of pilin post-translational modification on the shape and dynamics of microcolonies formed by Neisseria gonorrhoeae. Deleting the phosphotransferase responsible for phosphoethanolamine modification at residue serine 68 inhibits shape relaxations of microcolonies after perturbation and causes bacteria carrying the phosphoform modification to segregate to the surface of mixed colonies. We relate these mesoscopic phenotypes to increased attractive forces generated by T4P between cells. Moreover, by deleting genes responsible for the pilin glycan structure, we show that the number of saccharides attached at residue serine 63 affects the ratio between surface tension and viscosity and cause sorting between bacteria carrying different pilin glycoforms. We conclude that different pilin post-translational modifications moderately affect the attractive forces between bacteria but have severe effects on the material properties of microcolonies." @default.
- W2887569257 created "2018-08-22" @default.
- W2887569257 creator A5022345811 @default.
- W2887569257 creator A5023574267 @default.
- W2887569257 creator A5038946709 @default.
- W2887569257 creator A5068674965 @default.
- W2887569257 creator A5078759099 @default.
- W2887569257 creator A5081134287 @default.
- W2887569257 date "2019-03-01" @default.
- W2887569257 modified "2023-10-16" @default.
- W2887569257 title "Type IV Pilin Post-Translational Modifications Modulate Material Properties of Bacterial Colonies" @default.
- W2887569257 cites W1515133252 @default.
- W2887569257 cites W1835787045 @default.
- W2887569257 cites W1850654668 @default.
- W2887569257 cites W1867284802 @default.
- W2887569257 cites W1969886111 @default.
- W2887569257 cites W1977973890 @default.
- W2887569257 cites W1991037583 @default.
- W2887569257 cites W1993052488 @default.
- W2887569257 cites W1994889554 @default.
- W2887569257 cites W1995208961 @default.
- W2887569257 cites W2002785668 @default.
- W2887569257 cites W2006538777 @default.
- W2887569257 cites W2012325092 @default.
- W2887569257 cites W2019500447 @default.
- W2887569257 cites W2025560507 @default.
- W2887569257 cites W2040854131 @default.
- W2887569257 cites W2078077098 @default.
- W2887569257 cites W2096401127 @default.
- W2887569257 cites W2105177933 @default.
- W2887569257 cites W2109144745 @default.
- W2887569257 cites W2109368512 @default.
- W2887569257 cites W2111308926 @default.
- W2887569257 cites W2121811021 @default.
- W2887569257 cites W2124559749 @default.
- W2887569257 cites W2132927585 @default.
- W2887569257 cites W2148634126 @default.
- W2887569257 cites W2150588024 @default.
- W2887569257 cites W2153773689 @default.
- W2887569257 cites W2160208907 @default.
- W2887569257 cites W2163819538 @default.
- W2887569257 cites W2167084558 @default.
- W2887569257 cites W2221789832 @default.
- W2887569257 cites W2267446635 @default.
- W2887569257 cites W2560589824 @default.
- W2887569257 cites W2568689786 @default.
- W2887569257 cites W2586862576 @default.
- W2887569257 cites W2624150962 @default.
- W2887569257 cites W2724541800 @default.
- W2887569257 cites W2756166562 @default.
- W2887569257 cites W2794269287 @default.
- W2887569257 cites W2804040753 @default.
- W2887569257 cites W2892311748 @default.
- W2887569257 doi "https://doi.org/10.1016/j.bpj.2019.01.020" @default.
- W2887569257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400827" @default.
- W2887569257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30739725" @default.
- W2887569257 hasPublicationYear "2019" @default.
- W2887569257 type Work @default.
- W2887569257 sameAs 2887569257 @default.
- W2887569257 citedByCount "12" @default.
- W2887569257 countsByYear W28875692572019 @default.
- W2887569257 countsByYear W28875692572020 @default.
- W2887569257 countsByYear W28875692572021 @default.
- W2887569257 countsByYear W28875692572022 @default.
- W2887569257 countsByYear W28875692572023 @default.
- W2887569257 crossrefType "journal-article" @default.
- W2887569257 hasAuthorship W2887569257A5022345811 @default.
- W2887569257 hasAuthorship W2887569257A5023574267 @default.
- W2887569257 hasAuthorship W2887569257A5038946709 @default.
- W2887569257 hasAuthorship W2887569257A5068674965 @default.
- W2887569257 hasAuthorship W2887569257A5078759099 @default.
- W2887569257 hasAuthorship W2887569257A5081134287 @default.
- W2887569257 hasBestOaLocation W28875692571 @default.
- W2887569257 hasConcept C104317684 @default.
- W2887569257 hasConcept C12554922 @default.
- W2887569257 hasConcept C174832134 @default.
- W2887569257 hasConcept C185592680 @default.
- W2887569257 hasConcept C2776803919 @default.
- W2887569257 hasConcept C523546767 @default.
- W2887569257 hasConcept C54355233 @default.
- W2887569257 hasConcept C547475151 @default.
- W2887569257 hasConcept C55493867 @default.
- W2887569257 hasConcept C58123911 @default.
- W2887569257 hasConcept C86803240 @default.
- W2887569257 hasConceptScore W2887569257C104317684 @default.
- W2887569257 hasConceptScore W2887569257C12554922 @default.
- W2887569257 hasConceptScore W2887569257C174832134 @default.
- W2887569257 hasConceptScore W2887569257C185592680 @default.
- W2887569257 hasConceptScore W2887569257C2776803919 @default.
- W2887569257 hasConceptScore W2887569257C523546767 @default.
- W2887569257 hasConceptScore W2887569257C54355233 @default.
- W2887569257 hasConceptScore W2887569257C547475151 @default.
- W2887569257 hasConceptScore W2887569257C55493867 @default.
- W2887569257 hasConceptScore W2887569257C58123911 @default.
- W2887569257 hasConceptScore W2887569257C86803240 @default.
- W2887569257 hasFunder F4320320879 @default.
- W2887569257 hasIssue "5" @default.
- W2887569257 hasLocation W28875692571 @default.