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- W2887604140 abstract "Objective— We attempted to determine the molecular mechanism of fluid shear stress–induced lipocalin-type prostaglandin D synthase (l-PGDS) expression in vascular endothelial cells. Methods and Results— We examined the promoter region of the l-PGDS gene by loading laminar shear stress (20 dyne/cm2), using a parallel-plate flow chamber, on endothelial cells transfected with luciferase reporter vectors containing the 5′-flanking regions of the human l-PGDS gene. A deletion mutant analysis revealed that a shear stress–responsive element resided in the region between −2607 and −2523 bp. A mutation introduced into the putative binding site for activator protein-1 (AP-1) within this region eliminated the response to shear stress. In an electrophoretic mobility shift assay, shear stress stimulated nuclear protein binding to the AP-1 binding site, which was supershifted by antibodies to c-Fos and c-Jun. Shear stress elevated the c-Jun phosphorylation level in a time-dependent manner, similar to that of l-PGDS gen..." @default.
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- W2887604140 date "2005-05-01" @default.
- W2887604140 modified "2023-09-26" @default.
- W2887604140 title "Activator Protein-1 Mediates Shear Stress–Induced Prostaglandin D Synthase Gene Expression in Vascular Endothelial Cells" @default.
- W2887604140 hasPublicationYear "2005" @default.
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