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• W2887605039 abstract "INTRODUCTION: To develop a rat model of preeclampsia by administering bevacizumab, an angiogenesis inhibitor. METHODS: Sixteen pregnant rats were randomly allocated to intraperitoneal injection of 10 mg/kg bevacizumab or 0.1 cc intraperitoneal serum physiologic on the 4th and 8th days of gestation. Blood pressure, body weight, and proteinuria were measured on both day 0 (D0) and day 20 (D20). Blood samples were collected on D20 for analysis, including for determining vascular endothelial growth factor (VEGF) and soluble Fms-like tyrosine kinase 1 (sFlt-1) levels. On the same day, the mice were euthanized, the placentas and pups were weighted, and the angiogenesis markers and microvessel density were evaluated using immunohistochemical methods. RESULTS: Lower serum VEGF (p = 0.038) and higher SFlt-1 (p = 0.015) levels were observed in bevacizumab-treated pregnant rats. Bevacizumab-treated pregnant rats had significantly higher systolic (p = 0.050) and diastolic (p = 0.046) blood pressures compared to the controls. Additionally, the bevacizumab group showed a significant increase in proteinuria on D20 compared to that on D0 (p = 0.026). Although higher serum AST, ALT, BUN, and creatinine levels and renal glomerular endotheliosis scores as well as lower placental VEGF and microvessel density were noted in bevacizumab-treated rats, these differences were not statistically significant (p > 0.05 for each). DISCUSSION AND CONCLUSION: The promising results of this trial show that bevacizumab treatment in pregnant rats might provide a model to study human preeclampsia" @default.
• W2887605039 created "2018-08-22" @default.
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• W2887605039 date "2018-09-02" @default.
• W2887605039 modified "2023-09-25" @default.
• W2887605039 title "Gebe sıçanlara bevacizumab uygulayarak preeklampsi çalışmalarında kullanılabilecek deneysel hayvan modeli oluşturulabilir." @default.
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• W2887605039 doi "https://doi.org/10.31362/patd.451705" @default.
• W2887605039 hasPublicationYear "2018" @default.
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