FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887611106> ?p ?o ?g. }

• W2887611106 abstract "While lizards and salamanders both exhibit the ability to regenerate amputated tails, the outcomes achieved by each are markedly different. Salamanders, such as Ambystoma mexicanum, regenerate nearly identical copies of original tails. Regenerated lizard tails, however, exhibit important morphological differences compared with originals. Some of these differences concern dorsoventral patterning of regenerated skeletal and spinal cord tissues; regenerated salamander tail tissues exhibit dorsoventral patterning, while regrown lizard tissues do not. Additionally, regenerated lizard tails lack characteristically roof plate-associated structures, such as dorsal root ganglia. We hypothesized that differences in neural stem cells (NSCs) found in the ependyma of regenerated spinal cords account for these divergent regenerative outcomes. Through a combination of immunofluorescent staining, RT-PCR, hedgehog regulation, and transcriptome analysis, we analyzed NSC-dependent tail regeneration. Both salamander and lizard Sox2+ NSCs form neurospheres in culture. While salamander neurospheres exhibit default roof plate identity, lizard neurospheres exhibit default floor plate. Hedgehog signaling regulates dorsalization/ventralization of salamander, but not lizard, NSCs. Examination of NSC differentiation potential in vitro showed that salamander NSCs are capable of neural differentiation into multiple lineages, whereas lizard NSCs are not, which was confirmed by in vivo spinal cord transplantations. Finally, salamander NSCs xenogeneically transplanted into regenerating lizard tail spinal cords were influenced by native lizard NSC hedgehog signals, which favored salamander NSC floor plate differentiation. These findings suggest that NSCs in regenerated lizard and salamander spinal cords are distinct cell populations, and these differences contribute to the vastly different outcomes observed in tail regeneration." @default.
• W2887611106 created "2018-08-22" @default.
• W2887611106 creator A5022745271 @default.
• W2887611106 creator A5026064907 @default.
• W2887611106 creator A5034973849 @default.
• W2887611106 creator A5057499766 @default.
• W2887611106 creator A5057779968 @default.
• W2887611106 date "2018-08-13" @default.
• W2887611106 modified "2023-10-16" @default.
• W2887611106 title "Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders" @default.
• W2887611106 cites W105454707 @default.
• W2887611106 cites W1616179369 @default.
• W2887611106 cites W1643680178 @default.
• W2887611106 cites W1982780398 @default.
• W2887611106 cites W1987402927 @default.
• W2887611106 cites W2002457562 @default.
• W2887611106 cites W2018457977 @default.
• W2887611106 cites W2019331028 @default.
• W2887611106 cites W2020318740 @default.
• W2887611106 cites W2023228368 @default.
• W2887611106 cites W2026288887 @default.
• W2887611106 cites W2026599973 @default.
• W2887611106 cites W2029702685 @default.
• W2887611106 cites W2031233488 @default.
• W2887611106 cites W2043195047 @default.
• W2887611106 cites W2043979453 @default.
• W2887611106 cites W2066672792 @default.
• W2887611106 cites W2069111221 @default.
• W2887611106 cites W2074434145 @default.
• W2887611106 cites W2075994912 @default.
• W2887611106 cites W2079356804 @default.
• W2887611106 cites W2084652820 @default.
• W2887611106 cites W2111605071 @default.
• W2887611106 cites W2115298871 @default.
• W2887611106 cites W2117770258 @default.
• W2887611106 cites W2118393979 @default.
• W2887611106 cites W2120760574 @default.
• W2887611106 cites W2150612768 @default.
• W2887611106 cites W2150761291 @default.
• W2887611106 cites W2150817988 @default.
• W2887611106 cites W2151729211 @default.
• W2887611106 cites W2155360968 @default.
• W2887611106 cites W2173349550 @default.
• W2887611106 cites W2179863929 @default.
• W2887611106 cites W2207941023 @default.
• W2887611106 cites W2289769937 @default.
• W2887611106 cites W2343303489 @default.
• W2887611106 cites W2460285818 @default.
• W2887611106 cites W2485693821 @default.
• W2887611106 cites W2494553144 @default.
• W2887611106 cites W2622317584 @default.
• W2887611106 cites W2764284015 @default.
• W2887611106 cites W2766378398 @default.
• W2887611106 cites W2789769188 @default.
• W2887611106 doi "https://doi.org/10.1073/pnas.1803780115" @default.
• W2887611106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6126763" @default.
• W2887611106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30104374" @default.
• W2887611106 hasPublicationYear "2018" @default.
• W2887611106 type Work @default.
• W2887611106 sameAs 2887611106 @default.
• W2887611106 citedByCount "25" @default.
• W2887611106 countsByYear W28876111062019 @default.
• W2887611106 countsByYear W28876111062020 @default.
• W2887611106 countsByYear W28876111062021 @default.
• W2887611106 countsByYear W28876111062022 @default.
• W2887611106 countsByYear W28876111062023 @default.
• W2887611106 crossrefType "journal-article" @default.
• W2887611106 hasAuthorship W2887611106A5022745271 @default.
• W2887611106 hasAuthorship W2887611106A5026064907 @default.
• W2887611106 hasAuthorship W2887611106A5034973849 @default.
• W2887611106 hasAuthorship W2887611106A5057499766 @default.
• W2887611106 hasAuthorship W2887611106A5057779968 @default.
• W2887611106 hasBestOaLocation W28876111061 @default.
• W2887611106 hasConcept C104317684 @default.
• W2887611106 hasConcept C105702510 @default.
• W2887611106 hasConcept C136834591 @default.
• W2887611106 hasConcept C148738053 @default.
• W2887611106 hasConcept C162746124 @default.
• W2887611106 hasConcept C171056886 @default.
• W2887611106 hasConcept C20875687 @default.
• W2887611106 hasConcept C2777871726 @default.
• W2887611106 hasConcept C2779945282 @default.
• W2887611106 hasConcept C2779999439 @default.
• W2887611106 hasConcept C28328180 @default.
• W2887611106 hasConcept C2908669727 @default.
• W2887611106 hasConcept C54355233 @default.
• W2887611106 hasConcept C86803240 @default.
• W2887611106 hasConcept C90856448 @default.
• W2887611106 hasConcept C95444343 @default.
• W2887611106 hasConceptScore W2887611106C104317684 @default.
• W2887611106 hasConceptScore W2887611106C105702510 @default.
• W2887611106 hasConceptScore W2887611106C136834591 @default.
• W2887611106 hasConceptScore W2887611106C148738053 @default.
• W2887611106 hasConceptScore W2887611106C162746124 @default.
• W2887611106 hasConceptScore W2887611106C171056886 @default.
• W2887611106 hasConceptScore W2887611106C20875687 @default.
• W2887611106 hasConceptScore W2887611106C2777871726 @default.
• W2887611106 hasConceptScore W2887611106C2779945282 @default.
• W2887611106 hasConceptScore W2887611106C2779999439 @default.
• W2887611106 hasConceptScore W2887611106C28328180 @default.

• next