Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887612820> ?p ?o ?g. }
- W2887612820 endingPage "498" @default.
- W2887612820 startingPage "491" @default.
- W2887612820 abstract "The rearrangement and expression of immunoglobulin genes are regulated by enhancers and their binding transcriptional factors that activate or suppress the activities of the enhancers. The immunoglobulin κ (Igκ) gene locus has three important enhancers: the intrinsic enhancer (Ei), 3' enhancer (E3'), and distal enhancer (Ed). Ei and E3' are both required for Igκ gene rearrangement during early stages of B-cell development, whereas optimal expression of the rearranged Igκ gene relies on both E3' and Ed. The transcription factor YY1 affects the expression of many genes involved in B-cell development, probably by mediating interactions between their enhancers and promoters. Herein, we found that YY1 binds to the E3' enhancer and suppresses Igκ expression in B lymphoma cells by epigenetically modifying the enhancer. Knocking down YY1 enhanced Igκ expression, which was associated with increased levels of E2A (encoded by the TCF3 gene) and its binding to the E3' enhancer. Moreover, in germinal centre B cells and plasma cells, YY1 expression was reversely associated with Igκ levels, implying that YY1 might facilitate antibody affinity maturation in germinal centre B cells through the transient attenuation of Igκ expression." @default.
- W2887612820 created "2018-08-22" @default.
- W2887612820 creator A5009868338 @default.
- W2887612820 creator A5029363724 @default.
- W2887612820 creator A5032223964 @default.
- W2887612820 creator A5039117237 @default.
- W2887612820 creator A5049346557 @default.
- W2887612820 creator A5061633563 @default.
- W2887612820 creator A5073501391 @default.
- W2887612820 creator A5085845869 @default.
- W2887612820 creator A5089451798 @default.
- W2887612820 date "2018-08-29" @default.
- W2887612820 modified "2023-10-17" @default.
- W2887612820 title "YY1 binds to the E3ʹ enhancer and inhibits the expression of the immunoglobulin <i>κ</i> gene via epigenetic modifications" @default.
- W2887612820 cites W1773874353 @default.
- W2887612820 cites W1856742644 @default.
- W2887612820 cites W1936861715 @default.
- W2887612820 cites W1967867591 @default.
- W2887612820 cites W1982108913 @default.
- W2887612820 cites W1983916727 @default.
- W2887612820 cites W1986586739 @default.
- W2887612820 cites W1990793482 @default.
- W2887612820 cites W2008674168 @default.
- W2887612820 cites W2009740988 @default.
- W2887612820 cites W2014359105 @default.
- W2887612820 cites W2028601867 @default.
- W2887612820 cites W2038589622 @default.
- W2887612820 cites W2059880417 @default.
- W2887612820 cites W2086350426 @default.
- W2887612820 cites W2086390615 @default.
- W2887612820 cites W2095718954 @default.
- W2887612820 cites W2099673856 @default.
- W2887612820 cites W2107243811 @default.
- W2887612820 cites W2111626213 @default.
- W2887612820 cites W2126003544 @default.
- W2887612820 cites W2128591721 @default.
- W2887612820 cites W2141786556 @default.
- W2887612820 cites W2154284135 @default.
- W2887612820 cites W2158849813 @default.
- W2887612820 cites W2161881866 @default.
- W2887612820 cites W2204751602 @default.
- W2887612820 cites W2221403975 @default.
- W2887612820 cites W2264971900 @default.
- W2887612820 cites W2323028794 @default.
- W2887612820 cites W2367286278 @default.
- W2887612820 cites W2414500952 @default.
- W2887612820 cites W2470638261 @default.
- W2887612820 cites W2502342512 @default.
- W2887612820 cites W2595956860 @default.
- W2887612820 cites W2605350170 @default.
- W2887612820 cites W2774733631 @default.
- W2887612820 cites W4239864664 @default.
- W2887612820 doi "https://doi.org/10.1111/imm.12990" @default.
- W2887612820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231012" @default.
- W2887612820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30098214" @default.
- W2887612820 hasPublicationYear "2018" @default.
- W2887612820 type Work @default.
- W2887612820 sameAs 2887612820 @default.
- W2887612820 citedByCount "6" @default.
- W2887612820 countsByYear W28876128202019 @default.
- W2887612820 countsByYear W28876128202020 @default.
- W2887612820 countsByYear W28876128202021 @default.
- W2887612820 countsByYear W28876128202023 @default.
- W2887612820 crossrefType "journal-article" @default.
- W2887612820 hasAuthorship W2887612820A5009868338 @default.
- W2887612820 hasAuthorship W2887612820A5029363724 @default.
- W2887612820 hasAuthorship W2887612820A5032223964 @default.
- W2887612820 hasAuthorship W2887612820A5039117237 @default.
- W2887612820 hasAuthorship W2887612820A5049346557 @default.
- W2887612820 hasAuthorship W2887612820A5061633563 @default.
- W2887612820 hasAuthorship W2887612820A5073501391 @default.
- W2887612820 hasAuthorship W2887612820A5085845869 @default.
- W2887612820 hasAuthorship W2887612820A5089451798 @default.
- W2887612820 hasBestOaLocation W28876128201 @default.
- W2887612820 hasConcept C101762097 @default.
- W2887612820 hasConcept C104317684 @default.
- W2887612820 hasConcept C111936080 @default.
- W2887612820 hasConcept C150194340 @default.
- W2887612820 hasConcept C153911025 @default.
- W2887612820 hasConcept C159654299 @default.
- W2887612820 hasConcept C165864922 @default.
- W2887612820 hasConcept C21784809 @default.
- W2887612820 hasConcept C2778453870 @default.
- W2887612820 hasConcept C3020196193 @default.
- W2887612820 hasConcept C41091548 @default.
- W2887612820 hasConcept C54355233 @default.
- W2887612820 hasConcept C62944979 @default.
- W2887612820 hasConcept C86339819 @default.
- W2887612820 hasConcept C86803240 @default.
- W2887612820 hasConcept C96926380 @default.
- W2887612820 hasConceptScore W2887612820C101762097 @default.
- W2887612820 hasConceptScore W2887612820C104317684 @default.
- W2887612820 hasConceptScore W2887612820C111936080 @default.
- W2887612820 hasConceptScore W2887612820C150194340 @default.
- W2887612820 hasConceptScore W2887612820C153911025 @default.
- W2887612820 hasConceptScore W2887612820C159654299 @default.
- W2887612820 hasConceptScore W2887612820C165864922 @default.
- W2887612820 hasConceptScore W2887612820C21784809 @default.