FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887614555> ?p ?o ?g. }

• W2887614555 endingPage "912" @default.
• W2887614555 startingPage "904" @default.
• W2887614555 abstract "The matricellular protein SPARC (secreted proteome acidic and rich in cysteine) is known to bind collagens and regulate fibrillogenesis. Cleavage of SPARC at a single peptide bond, increases the affinity for collagens up to 20-fold. To investigate if this specific cleavage has pathological relevance in fibrotic disorders, we developed a competitive ELISA targeting the generated neo-epitope on the released fragment and quantified it in serum from patients with lung cancer, idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and healthy subjects. Furthermore, the ability of SPARC to protect fibrillar collagens from proteolytic degradation was investigated in vitro, potentially adding a new collagen chaperone function to SPARC. The fragment was significantly elevated in lung cancer patients when compared to healthy subjects measured in a discovery cohort (p = 0.0005) and a validation cohort (p < 0.0001). No significant difference was observed for IPF and COPD patients compared to healthy subjects. When recombinant SPARC was incubated with type I or type III collagen and matrix metalloproteinase-9, collagen degradation was completely inhibited. Together, these data suggest that cleavage of SPARC at a specific site, which modulates collagen binding, is a physiological mechanism increased during pathogenesis of lung cancer. Furthermore, inhibition of fibrillar collagen degradation by SPARC adds a new chaperone function to SPARC which may play additional roles in the contribution to increased collagen deposition leading to a pro-fibrotic and tumorigenic environment." @default.
• W2887614555 created "2018-08-22" @default.
• W2887614555 creator A5015629799 @default.
• W2887614555 creator A5049099295 @default.
• W2887614555 creator A5054029103 @default.
• W2887614555 creator A5054710115 @default.
• W2887614555 creator A5062465642 @default.
• W2887614555 creator A5081281256 @default.
• W2887614555 creator A5087875931 @default.
• W2887614555 date "2018-08-01" @default.
• W2887614555 modified "2023-10-02" @default.
• W2887614555 title "A fragment of SPARC reflecting increased collagen affinity shows pathological relevance in lung cancer – implications of a new collagen chaperone function of SPARC" @default.
• W2887614555 cites W134868223 @default.
• W2887614555 cites W1571232771 @default.
• W2887614555 cites W1605283518 @default.
• W2887614555 cites W1787080797 @default.
• W2887614555 cites W1966616396 @default.
• W2887614555 cites W1969497590 @default.
• W2887614555 cites W1974021786 @default.
• W2887614555 cites W1974719543 @default.
• W2887614555 cites W1975977239 @default.
• W2887614555 cites W1980867284 @default.
• W2887614555 cites W1982475740 @default.
• W2887614555 cites W1983704932 @default.
• W2887614555 cites W1983742309 @default.
• W2887614555 cites W1986676191 @default.
• W2887614555 cites W1987239717 @default.
• W2887614555 cites W1997961928 @default.
• W2887614555 cites W2001362512 @default.
• W2887614555 cites W2017441274 @default.
• W2887614555 cites W2026274081 @default.
• W2887614555 cites W2029697713 @default.
• W2887614555 cites W2031224113 @default.
• W2887614555 cites W2046246972 @default.
• W2887614555 cites W2056875960 @default.
• W2887614555 cites W2057490727 @default.
• W2887614555 cites W2066801055 @default.
• W2887614555 cites W2074017212 @default.
• W2887614555 cites W2080798474 @default.
• W2887614555 cites W2087024930 @default.
• W2887614555 cites W2087173527 @default.
• W2887614555 cites W2093896034 @default.
• W2887614555 cites W2097023891 @default.
• W2887614555 cites W2121780717 @default.
• W2887614555 cites W2127186381 @default.
• W2887614555 cites W2137331183 @default.
• W2887614555 cites W2137823978 @default.
• W2887614555 cites W2140698023 @default.
• W2887614555 cites W2175532272 @default.
• W2887614555 cites W2288411839 @default.
• W2887614555 cites W2533217592 @default.
• W2887614555 cites W4229997452 @default.
• W2887614555 cites W4250669271 @default.
• W2887614555 cites W4256143369 @default.
• W2887614555 doi "https://doi.org/10.1080/15384047.2018.1480887" @default.
• W2887614555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6300351" @default.
• W2887614555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30067436" @default.
• W2887614555 hasPublicationYear "2018" @default.
• W2887614555 type Work @default.
• W2887614555 sameAs 2887614555 @default.
• W2887614555 citedByCount "22" @default.
• W2887614555 countsByYear W28876145552019 @default.
• W2887614555 countsByYear W28876145552020 @default.
• W2887614555 countsByYear W28876145552021 @default.
• W2887614555 countsByYear W28876145552022 @default.
• W2887614555 countsByYear W28876145552023 @default.
• W2887614555 crossrefType "journal-article" @default.
• W2887614555 hasAuthorship W2887614555A5015629799 @default.
• W2887614555 hasAuthorship W2887614555A5049099295 @default.
• W2887614555 hasAuthorship W2887614555A5054029103 @default.
• W2887614555 hasAuthorship W2887614555A5054710115 @default.
• W2887614555 hasAuthorship W2887614555A5062465642 @default.
• W2887614555 hasAuthorship W2887614555A5081281256 @default.
• W2887614555 hasAuthorship W2887614555A5087875931 @default.
• W2887614555 hasBestOaLocation W28876145551 @default.
• W2887614555 hasConcept C109523444 @default.
• W2887614555 hasConcept C126322002 @default.
• W2887614555 hasConcept C131075544 @default.
• W2887614555 hasConcept C142724271 @default.
• W2887614555 hasConcept C160160445 @default.
• W2887614555 hasConcept C181199279 @default.
• W2887614555 hasConcept C185592680 @default.
• W2887614555 hasConcept C189165786 @default.
• W2887614555 hasConcept C2775893135 @default.
• W2887614555 hasConcept C2775962898 @default.
• W2887614555 hasConcept C2776256026 @default.
• W2887614555 hasConcept C2776780178 @default.
• W2887614555 hasConcept C2777714996 @default.
• W2887614555 hasConcept C2778341716 @default.
• W2887614555 hasConcept C2779335624 @default.
• W2887614555 hasConcept C2779794767 @default.
• W2887614555 hasConcept C2780559512 @default.
• W2887614555 hasConcept C2780644872 @default.
• W2887614555 hasConcept C2780942790 @default.
• W2887614555 hasConcept C2781460891 @default.
• W2887614555 hasConcept C38008103 @default.
• W2887614555 hasConcept C502942594 @default.
• W2887614555 hasConcept C55493867 @default.

• next