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- W2887645622 abstract "Therapeutic cell mimicry aims to provide a source of cell-like assemblies, which exhibit the core structural or functional properties of their natural counterparts with broad envisioned applications in biomedicine. Bone tissue engineering (BTE) aims at promoting and inciting the natural healing process of, for instance, critically sized bone defects. Microreactors designed to co-assemble with biological bone-forming osteoblasts like SaOS-2 cells to start biomineralization are reported for the first time. The alginate-based microparticles are equipped with active alkaline phosphatase-loaded artificial liposomes or SaOS-2-derived matrix vesicles (MVs). Spheroids assembled from SaOS-2 cells and microreactors not only exhibit higher cell viability, but also show enhanced biomineralization when MVs are present. The active biomineralization stimulation of the microreactors is illustrated by colorimetric calcium quantification and micro-computed tomography. These findings show the promising potential of applying cell mimicry in BTE." @default.
- W2887645622 created "2018-08-22" @default.
- W2887645622 creator A5031432808 @default.
- W2887645622 creator A5044749762 @default.
- W2887645622 creator A5062053719 @default.
- W2887645622 date "2018-08-16" @default.
- W2887645622 modified "2023-09-24" @default.
- W2887645622 title "Matrix Vesicles-Containing Microreactors as Support for Bonelike Osteoblasts to Enhance Biomineralization" @default.
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- W2887645622 doi "https://doi.org/10.1021/acsami.8b10886" @default.
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- W2887645622 hasPublicationYear "2018" @default.
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