FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887651337> ?p ?o ?g. }

• W2887651337 endingPage "1633" @default.
• W2887651337 startingPage "1626" @default.
• W2887651337 abstract "BACKGROUND Neuroblastomas (NBs) exhibit a wide variety of clinical behavior. It is important to determine the biology of NB before treatment is instituted. METHODS One hundred six NBs detected clinically (clinical NBs) were classified according to immunohistochemical expression of the Ha-ras and trk A genes. Association of the two-gene expression with patient outcome was examined retrospectively, and the possibility of prognostic prediction was evaluated. The profile of the expression of the two genes in 85 NBs detected through mass screening (mass NBs) was compared with that in clinical NBs. RESULTS Ha-ras/trk A expression in clinical NBs was associated with disease free survival, even when the NBs had no amplification of the N-myc gene. Multivariate analysis demonstrated that the expression of Ha-ras/trk A was a significant prognostic factor that was independent of stage, age at diagnosis, and N-myc amplification. Favorable outcomes of patients with advanced NB were distinguished by high Ha-ras and high trk A expression, and unfavorable outcomes were distinguished by low Ha-ras and low trk A expression. A profile of the two genes in mass NBs was different from that in clinical NBs. Greater than 50% of the mass NBs were detected as localized tumors with high Ha-ras and high trk A expression. The mass screening detected NBs with favorable and unfavorable biology. CONCLUSIONS The expression of Ha-ras and trk A is an excellent predictor of both favorable and unfavorable biology in NBs. The information it provides can be important in determining the appropriate therapeutic intervention for each patient. Cancer 1998;83:1626-1633. © 1998 American Cancer Society." @default.
• W2887651337 created "2018-08-22" @default.
• W2887651337 creator A5009165742 @default.
• W2887651337 creator A5059891995 @default.
• W2887651337 creator A5085437482 @default.
• W2887651337 date "1998-10-15" @default.
• W2887651337 modified "2023-10-17" @default.
• W2887651337 title "Prognostic discrimination among neuroblastomas according to ha-ras/trk A gene expression" @default.
• W2887651337 cites W1590871522 @default.
• W2887651337 cites W1965694113 @default.
• W2887651337 cites W1965864793 @default.
• W2887651337 cites W1970380630 @default.
• W2887651337 cites W1978798502 @default.
• W2887651337 cites W1981801262 @default.
• W2887651337 cites W1985417906 @default.
• W2887651337 cites W1988736907 @default.
• W2887651337 cites W1993610674 @default.
• W2887651337 cites W1997916538 @default.
• W2887651337 cites W2004859290 @default.
• W2887651337 cites W2008115232 @default.
• W2887651337 cites W2010488494 @default.
• W2887651337 cites W2012219845 @default.
• W2887651337 cites W2014250705 @default.
• W2887651337 cites W2014866230 @default.
• W2887651337 cites W2022870173 @default.
• W2887651337 cites W2030806984 @default.
• W2887651337 cites W2031444823 @default.
• W2887651337 cites W2051440419 @default.
• W2887651337 cites W2061438510 @default.
• W2887651337 cites W2069132844 @default.
• W2887651337 cites W2074659620 @default.
• W2887651337 cites W2078626049 @default.
• W2887651337 cites W2086226581 @default.
• W2887651337 cites W2087723071 @default.
• W2887651337 cites W2095041773 @default.
• W2887651337 cites W2107573167 @default.
• W2887651337 cites W2139685495 @default.
• W2887651337 cites W2326401583 @default.
• W2887651337 cites W2330923897 @default.
• W2887651337 cites W4235538535 @default.
• W2887651337 cites W4242642752 @default.
• W2887651337 doi "https://doi.org/10.1002/(sici)1097-0142(19981015)83:8<1626::aid-cncr19>3.0.co;2-y" @default.
• W2887651337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9781958" @default.
• W2887651337 hasPublicationYear "1998" @default.
• W2887651337 type Work @default.
• W2887651337 sameAs 2887651337 @default.
• W2887651337 citedByCount "42" @default.
• W2887651337 countsByYear W28876513372012 @default.
• W2887651337 countsByYear W28876513372014 @default.
• W2887651337 countsByYear W28876513372016 @default.
• W2887651337 crossrefType "journal-article" @default.
• W2887651337 hasAuthorship W2887651337A5009165742 @default.
• W2887651337 hasAuthorship W2887651337A5059891995 @default.
• W2887651337 hasAuthorship W2887651337A5085437482 @default.
• W2887651337 hasBestOaLocation W28876513371 @default.
• W2887651337 hasConcept C104317684 @default.
• W2887651337 hasConcept C126322002 @default.
• W2887651337 hasConcept C134139212 @default.
• W2887651337 hasConcept C143998085 @default.
• W2887651337 hasConcept C150194340 @default.
• W2887651337 hasConcept C170493617 @default.
• W2887651337 hasConcept C204232928 @default.
• W2887651337 hasConcept C2776715637 @default.
• W2887651337 hasConcept C502942594 @default.
• W2887651337 hasConcept C54355233 @default.
• W2887651337 hasConcept C71924100 @default.
• W2887651337 hasConcept C81885089 @default.
• W2887651337 hasConcept C86803240 @default.
• W2887651337 hasConcept C92020748 @default.
• W2887651337 hasConceptScore W2887651337C104317684 @default.
• W2887651337 hasConceptScore W2887651337C126322002 @default.
• W2887651337 hasConceptScore W2887651337C134139212 @default.
• W2887651337 hasConceptScore W2887651337C143998085 @default.
• W2887651337 hasConceptScore W2887651337C150194340 @default.
• W2887651337 hasConceptScore W2887651337C170493617 @default.
• W2887651337 hasConceptScore W2887651337C204232928 @default.
• W2887651337 hasConceptScore W2887651337C2776715637 @default.
• W2887651337 hasConceptScore W2887651337C502942594 @default.
• W2887651337 hasConceptScore W2887651337C54355233 @default.
• W2887651337 hasConceptScore W2887651337C71924100 @default.
• W2887651337 hasConceptScore W2887651337C81885089 @default.
• W2887651337 hasConceptScore W2887651337C86803240 @default.
• W2887651337 hasConceptScore W2887651337C92020748 @default.
• W2887651337 hasIssue "8" @default.
• W2887651337 hasLocation W28876513371 @default.
• W2887651337 hasLocation W28876513372 @default.
• W2887651337 hasOpenAccess W2887651337 @default.
• W2887651337 hasPrimaryLocation W28876513371 @default.
• W2887651337 hasRelatedWork W2006225931 @default.
• W2887651337 hasRelatedWork W2054436155 @default.
• W2887651337 hasRelatedWork W2140366271 @default.
• W2887651337 hasRelatedWork W2144198186 @default.
• W2887651337 hasRelatedWork W2163763677 @default.
• W2887651337 hasRelatedWork W2465728417 @default.
• W2887651337 hasRelatedWork W2921461273 @default.
• W2887651337 hasRelatedWork W3031906512 @default.
• W2887651337 hasRelatedWork W3174719410 @default.
• W2887651337 hasRelatedWork W4282601439 @default.

• next