Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887653659> ?p ?o ?g. }
- W2887653659 abstract "Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32γ) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance." @default.
- W2887653659 created "2018-08-22" @default.
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- W2887653659 date "2018-08-16" @default.
- W2887653659 modified "2023-10-16" @default.
- W2887653659 title "Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus" @default.
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- W2887653659 doi "https://doi.org/10.1038/s41467-018-05782-5" @default.
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- W2887653659 hasPublicationYear "2018" @default.
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