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• W2887662227 endingPage "10" @default.
• W2887662227 startingPage "5" @default.
• W2887662227 abstract "Fluorescent copper nanoslusters (CuNCs) as a new class of fluorophores have attracted more and more attention due to their ease of synthesis, excellent optical properties, and low cost. In this study, a novel label-free fluorescent method was developed for the detection of DNA methyltransferases based on template length-dependent of dsDNA-CuNCs. In the absence of DNA adenine methylation methyltransferase (Dam MTase), the dsDNA containing the methylation-responsive sequence could effectively template the formation of fluorescent CuNCs with bright fluorescence. When the dsDNA substrate is methylated by Dam MTase, the methylation-sensitive restriction endonuclease Dpn I cleaves the methylated dsDNA and produces shorter dsDNA product, which fails to template fluorescent CuNCs. So, the Dam MTase activity could be identified by the changes of CuNCs' fluorescence. Based on this method, a linear range of 0.5–10 U/mL was achieved with high sensitivity and selectivity. Moreover, we also demonstrate the proposed method can be applied to evaluation and screening of inhibitors for Dam MTase." @default.
• W2887662227 created "2018-08-22" @default.
• W2887662227 creator A5003065832 @default.
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• W2887662227 date "2018-10-01" @default.
• W2887662227 modified "2023-10-17" @default.
• W2887662227 title "Fluorescent copper nanoclusters as a nano-dye for DNA methyltransferase activity analysis and inhibitor screening" @default.
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• W2887662227 doi "https://doi.org/10.1016/j.ab.2018.08.011" @default.
• W2887662227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30120924" @default.
• W2887662227 hasPublicationYear "2018" @default.
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