FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887666943> ?p ?o ?g. }

• W2887666943 abstract "Intact amyloid-β peptides (Aβ) may undergo prion-like aggregation when they interact with chemically or structurally modified variants of Aβ present in extracellular pathohistological inclusions (amyloid plaques). This aggregation is regarded as one of the key molecular mechanisms of Alzheimer's disease (AD) pathogenesis. Zinc ions are involved in the pathological dimerization and oligomerization of natural Aβ isoforms, and zinc-induced oligomers can also initiate the pathological aggregation of Aβ. Based on the earlier found molecular mechanism of zinc-dependent oligomerization of Aβ, it has been suggested that the targeted inhibition of the 11EVHH14 site in one Aβ molecule from zinc-mediated interactions with the same site of another Aβ molecule can effectively inhibit the oligomerization and aggregation of Aβ. Taking into account the similarity in the structural organization of zinc-binding sites within Aβ and angiotensin-converting enzyme (ACE), we hypothesized that inhibitors of the ACE active sites could specifically interact with the 11EVHH14 site of Aβ. Using a surface plasmon resonance biosensor and nuclear magnetic resonance spectroscopy, we have found that the ACE inhibitor enalaprilat effectively inhibits zinc-dependent dimerization of the metal-binding domains of intact Aβ and Aβ with isomerized Asp7 (isoAβ). We have also found that enalaprilat protects SH-SY5Y human neuroblastoma cells from the toxic effects of Aβ(1-42) and isoAβ(1-42), which are among the most common components of amyloid plaques. The results confirm the role of zincdependent oligomerization of Aβ in AD pathogenesis and make it possible one to consider enalaprilat as a prototype of antiaggregation agents for treating AD." @default.
• W2887666943 created "2018-08-22" @default.
• W2887666943 creator A5003740484 @default.
• W2887666943 creator A5008227797 @default.
• W2887666943 creator A5023320155 @default.
• W2887666943 creator A5025842677 @default.
• W2887666943 creator A5037083772 @default.
• W2887666943 creator A5077027929 @default.
• W2887666943 creator A5084368816 @default.
• W2887666943 creator A5087267915 @default.
• W2887666943 creator A5090637711 @default.
• W2887666943 date "2018-01-01" @default.
• W2887666943 modified "2023-09-23" @default.
• W2887666943 title "Эналаприлат ингибирует цинкзависимую олигомеризацию металлсвязывающего домена изоформ бета-амилоида и защищает клетки нейробластомы человека от их токсического действия" @default.
• W2887666943 cites W1784444703 @default.
• W2887666943 cites W1892941700 @default.
• W2887666943 cites W1931295359 @default.
• W2887666943 cites W1944064480 @default.
• W2887666943 cites W1963885312 @default.
• W2887666943 cites W1969010189 @default.
• W2887666943 cites W1973970435 @default.
• W2887666943 cites W1974467644 @default.
• W2887666943 cites W1977308814 @default.
• W2887666943 cites W1981851263 @default.
• W2887666943 cites W1986284818 @default.
• W2887666943 cites W1989806335 @default.
• W2887666943 cites W1996241810 @default.
• W2887666943 cites W1999059983 @default.
• W2887666943 cites W2012665903 @default.
• W2887666943 cites W2016824661 @default.
• W2887666943 cites W2025200427 @default.
• W2887666943 cites W2037158866 @default.
• W2887666943 cites W2040650067 @default.
• W2887666943 cites W2040863516 @default.
• W2887666943 cites W2048228293 @default.
• W2887666943 cites W2055775253 @default.
• W2887666943 cites W2070085985 @default.
• W2887666943 cites W2088743030 @default.
• W2887666943 cites W2095674336 @default.
• W2887666943 cites W2107513734 @default.
• W2887666943 cites W2168945601 @default.
• W2887666943 cites W2171204153 @default.
• W2887666943 cites W2171887704 @default.
• W2887666943 cites W2277679914 @default.
• W2887666943 cites W2304739987 @default.
• W2887666943 cites W2329336071 @default.
• W2887666943 cites W2340500249 @default.
• W2887666943 cites W2405319444 @default.
• W2887666943 cites W2411391113 @default.
• W2887666943 cites W2414450014 @default.
• W2887666943 cites W2566363022 @default.
• W2887666943 cites W2572208524 @default.
• W2887666943 cites W2617072792 @default.
• W2887666943 cites W2620981135 @default.
• W2887666943 cites W2752287204 @default.
• W2887666943 cites W2768303128 @default.
• W2887666943 cites W2918066696 @default.
• W2887666943 cites W2934363364 @default.
• W2887666943 cites W2950276258 @default.
• W2887666943 cites W3014251530 @default.
• W2887666943 doi "https://doi.org/10.1134/s0026898418040109" @default.
• W2887666943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30113034" @default.
• W2887666943 hasPublicationYear "2018" @default.
• W2887666943 type Work @default.
• W2887666943 sameAs 2887666943 @default.
• W2887666943 citedByCount "4" @default.
• W2887666943 countsByYear W28876669432020 @default.
• W2887666943 countsByYear W28876669432022 @default.
• W2887666943 countsByYear W28876669432023 @default.
• W2887666943 crossrefType "journal-article" @default.
• W2887666943 hasAuthorship W2887666943A5003740484 @default.
• W2887666943 hasAuthorship W2887666943A5008227797 @default.
• W2887666943 hasAuthorship W2887666943A5023320155 @default.
• W2887666943 hasAuthorship W2887666943A5025842677 @default.
• W2887666943 hasAuthorship W2887666943A5037083772 @default.
• W2887666943 hasAuthorship W2887666943A5077027929 @default.
• W2887666943 hasAuthorship W2887666943A5084368816 @default.
• W2887666943 hasAuthorship W2887666943A5087267915 @default.
• W2887666943 hasAuthorship W2887666943A5090637711 @default.
• W2887666943 hasConcept C104317684 @default.
• W2887666943 hasConcept C106847996 @default.
• W2887666943 hasConcept C107824862 @default.
• W2887666943 hasConcept C12554922 @default.
• W2887666943 hasConcept C134018914 @default.
• W2887666943 hasConcept C155672457 @default.
• W2887666943 hasConcept C161624437 @default.
• W2887666943 hasConcept C171250308 @default.
• W2887666943 hasConcept C178790620 @default.
• W2887666943 hasConcept C179104552 @default.
• W2887666943 hasConcept C181199279 @default.
• W2887666943 hasConcept C185592680 @default.
• W2887666943 hasConcept C192562407 @default.
• W2887666943 hasConcept C203014093 @default.
• W2887666943 hasConcept C27016395 @default.
• W2887666943 hasConcept C2777633098 @default.
• W2887666943 hasConcept C2777814262 @default.
• W2887666943 hasConcept C2779611605 @default.
• W2887666943 hasConcept C2780942790 @default.
• W2887666943 hasConcept C28406088 @default.
• W2887666943 hasConcept C53345823 @default.

• next