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- W2887690994 abstract "The commitment to eliminate schistosomiasis as a public health problem has mobilized the expansion of praziquantel treatment to meet the London Declaration targets. New research has thus sought to elucidate praziquantel's safety and efficacy in key demographics such as preschoolers and pregnant women, as well as novel elements of its pharmacokinetics and pharmacodynamics. At the same time, reliance on praziquantel ad infinitum would place schistosomiasis control at risk, should resistance occur. In response, the academic community has been filling the pre-clinical drug discovery pipeline with novel or resurrected drug candidates against schistosomiasis. In this review, we highlight the latest research on praziquantel treatment dynamics, which aims to improve the utility of this important drug. Moreover, we present the most promising preclinical antischistosomal candidates, which should be studied further to achieve the ultimate goal- an alternative antischistosomal drug in the near future." @default.
- W2887690994 created "2018-08-22" @default.
- W2887690994 creator A5033452459 @default.
- W2887690994 creator A5059440013 @default.
- W2887690994 date "2018-10-01" @default.
- W2887690994 modified "2023-09-23" @default.
- W2887690994 title "Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads" @default.
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- W2887690994 doi "https://doi.org/10.1016/j.coph.2018.06.004" @default.
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