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• W2887707675 abstract "<b><i>Objectives:</i></b> Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. <b><i>Methods:</i></b> Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. <b><i>Results:</i></b> The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (<i>p</i> &#x3c; 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (<i>p</i> &#x3c; 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis." @default.
• W2887707675 created "2018-08-22" @default.
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• W2887707675 date "2018-01-01" @default.
• W2887707675 modified "2023-10-04" @default.
• W2887707675 title "High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy" @default.
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• W2887707675 doi "https://doi.org/10.1159/000490855" @default.
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