FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887723227> ?p ?o ?g. }

• W2887723227 abstract "Background and purpose: It is still not clear whether Notch1 signaling inhibition can promote functional outcomes after stroke, given that it plays time-dependent roles in the sequential process of endogenous neurogenesis. The purpose of this study was to identify the appropriate time frame for Notch1 signaling inhibition according to the temporal evolution of Notch1 signaling activation and the responses of neural stem cells (NSCs), in order to target it for therapeutic intervention and stimulate neurorestorative strategies after stroke. Methods: Sprague-Dawley (SD) rats were subjected to 90-minutes of middle cerebral artery occlusion (MCAO). Rats were sacrificed before, and at day 1, day 2, day 3, day 4, and day 7 after ischemia for immunohistochemical analysis of the Notch intracellular domain (NICD), Nestin and doublecortin (Dcx). Next, MCAO rats were treated with the γ-secretase inhibitor N‐[N‐(3,5‐di uorophenacetyl)‐1‐alanyl]‐S‐phenylglycine t-butylester (DAPT) or with saline at day 4 after ischemia, and subsequently evaluated with behavioral test analysis and magnetic resonance imaging (MRI). The rat brains were then harvested for immunohistochemical analysis of Dcx, NeuN and myelin basic protein (MBP) at 2 weeks, 3 weeks, 4 weeks, and 8 weeks. Results: Notch1 signaling was maximally activated at day 3 after ischemia in parallel with the temporal evolution of NSCs. Inhibiting Notch1 signaling at day 4 after reperfusion with DAPT further promoted recovery of MRI parameters of the corticospinal tract (CST) and the functional outcomes, concomitantly with an increase in neuroblasts, their migration to the ischemic boundary, and potential differentiation to mature neurons, as well as the amelioration of axonal bundle integrity. Conclusions: Inhibition of Notch1 signaling at the subacute stage of stroke could maximally promote endogenous neurogenesis and axonal reorganization." @default.
• W2887723227 created "2018-08-22" @default.
• W2887723227 creator A5012898417 @default.
• W2887723227 creator A5014029292 @default.
• W2887723227 creator A5028314471 @default.
• W2887723227 creator A5029146991 @default.
• W2887723227 creator A5063352951 @default.
• W2887723227 creator A5064923549 @default.
• W2887723227 creator A5065760891 @default.
• W2887723227 creator A5068918837 @default.
• W2887723227 date "2018-08-07" @default.
• W2887723227 modified "2023-10-16" @default.
• W2887723227 title "Inhibition of Notch1 Signaling at the Subacute Stage of Stroke Promotes Endogenous Neurogenesis and Motor Recovery After Stroke" @default.
• W2887723227 cites W1974649774 @default.
• W2887723227 cites W1988792859 @default.
• W2887723227 cites W1997801266 @default.
• W2887723227 cites W2004259291 @default.
• W2887723227 cites W2005450277 @default.
• W2887723227 cites W2013125297 @default.
• W2887723227 cites W2017765500 @default.
• W2887723227 cites W2032438124 @default.
• W2887723227 cites W2046463320 @default.
• W2887723227 cites W2047152236 @default.
• W2887723227 cites W2051594546 @default.
• W2887723227 cites W2057711793 @default.
• W2887723227 cites W2063018820 @default.
• W2887723227 cites W2065288737 @default.
• W2887723227 cites W2065584262 @default.
• W2887723227 cites W2071969118 @default.
• W2887723227 cites W2073633782 @default.
• W2887723227 cites W2080032473 @default.
• W2887723227 cites W2087514362 @default.
• W2887723227 cites W2092539348 @default.
• W2887723227 cites W2100453275 @default.
• W2887723227 cites W2112078005 @default.
• W2887723227 cites W2117987496 @default.
• W2887723227 cites W2126719211 @default.
• W2887723227 cites W2131456668 @default.
• W2887723227 cites W2137078662 @default.
• W2887723227 cites W2137329985 @default.
• W2887723227 cites W2139832849 @default.
• W2887723227 cites W2155661160 @default.
• W2887723227 cites W2156147499 @default.
• W2887723227 cites W2168272960 @default.
• W2887723227 cites W2238889775 @default.
• W2887723227 cites W2301610713 @default.
• W2887723227 cites W2443614248 @default.
• W2887723227 cites W2600283634 @default.
• W2887723227 cites W2744497761 @default.
• W2887723227 cites W2748010953 @default.
• W2887723227 doi "https://doi.org/10.3389/fncel.2018.00245" @default.
• W2887723227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6091141" @default.
• W2887723227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30131677" @default.
• W2887723227 hasPublicationYear "2018" @default.
• W2887723227 type Work @default.
• W2887723227 sameAs 2887723227 @default.
• W2887723227 citedByCount "19" @default.
• W2887723227 countsByYear W28877232272018 @default.
• W2887723227 countsByYear W28877232272019 @default.
• W2887723227 countsByYear W28877232272020 @default.
• W2887723227 countsByYear W28877232272022 @default.
• W2887723227 countsByYear W28877232272023 @default.
• W2887723227 crossrefType "journal-article" @default.
• W2887723227 hasAuthorship W2887723227A5012898417 @default.
• W2887723227 hasAuthorship W2887723227A5014029292 @default.
• W2887723227 hasAuthorship W2887723227A5028314471 @default.
• W2887723227 hasAuthorship W2887723227A5029146991 @default.
• W2887723227 hasAuthorship W2887723227A5063352951 @default.
• W2887723227 hasAuthorship W2887723227A5064923549 @default.
• W2887723227 hasAuthorship W2887723227A5065760891 @default.
• W2887723227 hasAuthorship W2887723227A5068918837 @default.
• W2887723227 hasBestOaLocation W28877232271 @default.
• W2887723227 hasConcept C126322002 @default.
• W2887723227 hasConcept C127413603 @default.
• W2887723227 hasConcept C136834591 @default.
• W2887723227 hasConcept C161879069 @default.
• W2887723227 hasConcept C169760540 @default.
• W2887723227 hasConcept C170493617 @default.
• W2887723227 hasConcept C204232928 @default.
• W2887723227 hasConcept C2776464000 @default.
• W2887723227 hasConcept C2777738006 @default.
• W2887723227 hasConcept C2778609137 @default.
• W2887723227 hasConcept C2778820722 @default.
• W2887723227 hasConcept C2780645631 @default.
• W2887723227 hasConcept C2780876595 @default.
• W2887723227 hasConcept C2781100881 @default.
• W2887723227 hasConcept C2781161787 @default.
• W2887723227 hasConcept C2781461022 @default.
• W2887723227 hasConcept C28328180 @default.
• W2887723227 hasConcept C39961270 @default.
• W2887723227 hasConcept C4746552 @default.
• W2887723227 hasConcept C529278444 @default.
• W2887723227 hasConcept C541997718 @default.
• W2887723227 hasConcept C71924100 @default.
• W2887723227 hasConcept C78519656 @default.
• W2887723227 hasConcept C86803240 @default.
• W2887723227 hasConcept C95444343 @default.
• W2887723227 hasConceptScore W2887723227C126322002 @default.
• W2887723227 hasConceptScore W2887723227C127413603 @default.
• W2887723227 hasConceptScore W2887723227C136834591 @default.

• next