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- W2887735589 abstract "Exposure to chronic hypoxia (CH) induces a sustained pulmonary hypertension associated with structural and functional changes in the pulmonary arterial bed, including alterations of contractile properties. The small G-protein RhoA and its effector Rho kinase play a major role in the sustained rise in tension induced by vasoconstrictors. The aim of this study was to analyze the effect of CH on the RhoA/Rho kinase signaling pathway in the rat pulmonary artery. Maximal contraction of pulmonary artery rings to endothelin-1, noradrenaline, and the thromboxane A2 analog U46619 was markedly decreased in rats exposed to CH (10% O2, 2 weeks). This CH-induced decrease response to agonists was attributable to the abolition of RhoA-mediated Ca2+ sensitization of the contraction. Real-time reverse transcriptase–polymerase chain reaction and Western blot analysis revealed a decrease in RhoA mRNA (79.4±6.0%, n=4) and RhoA (81.1±8.0%, n=4) expression in the main pulmonary artery from CH rats, whereas RhoA expression was ..." @default.
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- W2887735589 date "2003-10-03" @default.
- W2887735589 modified "2023-09-24" @default.
- W2887735589 title "Sildenafil Prevents Change in RhoA Expression Induced by Chronic Hypoxia in Rat Pulmonary Artery" @default.
- W2887735589 hasPublicationYear "2003" @default.
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