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- W2887751431 abstract "Abstract—The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In guinea pig hearts, AP durations (APDs) and RPs on the epicardium are shorter at the apex and progressively longer toward the base, producing gradients of RPs that may influence the spatial organization of VF. In the present study, the influence of APDs on VF dynamics is investigated in perfused guinea pig hearts stained with a voltage-sensitive dye by comparing APD gradients to the dynamics of VF elicited by burst pacing. In VF, AIs had no clear periodicity, but average AIs were shorter at the apex (57.5±8.1 ms) than the base (76.1±1.5 ms, n=6, P<0.05) and had gradients similar to APD gradients (correlation coefficient 0.71±0.04). Analysis of local velocity vectors showed no preferentia..." @default.
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- W2887751431 date "2001-03-16" @default.
- W2887751431 modified "2023-09-27" @default.
- W2887751431 title "The Distribution of Refractory Periods Influences the Dynamics of Ventricular Fibrillation" @default.
- W2887751431 hasPublicationYear "2001" @default.
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