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- W2887752022 abstract "Novel highly functionalized 2-amino-4H-pyrans were achieved in excellent yields under simple grinding at ambient temperature and were assessed for their potential for treating Alzheimer's disease (AD). The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 ± 0.09 µM against acetylcholinesterase (AChE) and 10.62 ± 0.21 µM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations." @default.
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- W2887752022 date "2018-12-01" @default.
- W2887752022 modified "2023-09-26" @default.
- W2887752022 title "Highly functionalized 2-amino-4H-pyrans as potent cholinesterase inhibitors" @default.
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- W2887752022 doi "https://doi.org/10.1016/j.bioorg.2018.08.009" @default.
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