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• W2887754584 abstract "Abstract Bacterial metabolism is fundamental to pathogenesis and has a dominant effect on bacterial killing by antibiotics. Here we explore how Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination of bacterial physiology and stable isotope tracing coupled to liquid chromatography mass spectrometry metabolomics methods. Our results define core properties of the nitrogen metabolic network from M. tuberculosis , such as: (i) the lack of homeostatic control of amino acid pool sizes; (ii) similar rates of utilisation of different amino acids as sole nitrogen sources; (iii) improved nitrogen utilisation from amino acids compared to ammonium; and (iv) co-metabolism of nitrogen sources. Finally, we discover that alanine dehydrogenase, is involved in ammonium assimilation in M. tuberculosis , in addition to its essential role in alanine utilisation. This study represents the first in-depth analysis of nitrogen source utilisation by metabolic generatlist M. tuberculosis and reveals a flexible metabolic network with characteristics that are likely product of evolution in the human host." @default.
• W2887754584 created "2018-08-22" @default.
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• W2887754584 date "2018-08-05" @default.
• W2887754584 modified "2023-09-23" @default.
• W2887754584 title "Nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis" @default.
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• W2887754584 doi "https://doi.org/10.1101/385278" @default.
• W2887754584 hasPublicationYear "2018" @default.
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