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- W2887755174 abstract "Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation inferior to surgical resection, the apparent selection bias when comparing patients with unresectable disease to surgical candidates, the superior safety profile, and the competitive overall survival results for the more recent reports mandate the setup of a randomized controlled trial. The objective of the COLLISION trial is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable CRLM and no extrahepatic disease. In this two-arm, single-blind multi-center phase-III clinical trial, six hundred and eighteen patients with at least one CRLM (≤3 cm) will be included to undergo either surgical resection or thermal ablation of appointed target lesion(s) (≤3 cm). Primary endpoint is OS (overall survival, intention-to-treat analysis). Main secondary endpoints are overall disease-free survival (DFS), time to progression (TTP), time to local progression (TTLP), primary and assisted technique efficacy (PTE, ATE), procedural morbidity and mortality, length of hospital stay, assessment of pain and quality of life (QoL), cost-effectiveness ratio (ICER) and quality-adjusted life years (QALY). If thermal ablation proves to be non-inferior in treating lesions ≤3 cm, a switch in treatment-method may lead to a reduction of the post-procedural morbidity and mortality, length of hospital stay and incremental costs without compromising oncological outcome for patients with CRLM. NCT03088150 , January 11th 2017." @default.
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- W2887755174 date "2018-08-15" @default.
- W2887755174 modified "2023-10-01" @default.
- W2887755174 title "Colorectal liver metastases: surgery versus thermal ablation (COLLISION) – a phase III single-blind prospective randomized controlled trial" @default.
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- W2887755174 cites W1981989535 @default.
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- W2887755174 cites W1986065465 @default.
- W2887755174 cites W1991958231 @default.
- W2887755174 cites W1994078883 @default.
- W2887755174 cites W1998111872 @default.
- W2887755174 cites W1999507792 @default.
- W2887755174 cites W2000180049 @default.
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- W2887755174 cites W2005750764 @default.
- W2887755174 cites W2007227758 @default.
- W2887755174 cites W2008547329 @default.
- W2887755174 cites W2018433986 @default.
- W2887755174 cites W2021594037 @default.
- W2887755174 cites W2025142440 @default.
- W2887755174 cites W2028564263 @default.
- W2887755174 cites W2029890275 @default.
- W2887755174 cites W2031439588 @default.
- W2887755174 cites W2034284109 @default.
- W2887755174 cites W2035964293 @default.
- W2887755174 cites W2046559051 @default.
- W2887755174 cites W2048809011 @default.
- W2887755174 cites W2055829950 @default.
- W2887755174 cites W2056000859 @default.
- W2887755174 cites W2060179234 @default.
- W2887755174 cites W2063270328 @default.
- W2887755174 cites W2064414057 @default.
- W2887755174 cites W2065539121 @default.
- W2887755174 cites W2066249590 @default.
- W2887755174 cites W2069610516 @default.
- W2887755174 cites W2070648012 @default.
- W2887755174 cites W2073086268 @default.
- W2887755174 cites W2076187733 @default.
- W2887755174 cites W2078024473 @default.
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- W2887755174 cites W2094360299 @default.
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- W2887755174 cites W2124036501 @default.
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- W2887755174 cites W2147917585 @default.
- W2887755174 cites W2152740887 @default.
- W2887755174 cites W2157769714 @default.
- W2887755174 cites W2167512218 @default.
- W2887755174 cites W2169790053 @default.
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- W2887755174 cites W2241196545 @default.
- W2887755174 cites W2333857317 @default.
- W2887755174 cites W2394944259 @default.
- W2887755174 cites W2398409601 @default.
- W2887755174 cites W2414673346 @default.
- W2887755174 cites W2596956169 @default.
- W2887755174 cites W2786875351 @default.
- W2887755174 cites W2802733522 @default.
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- W2887755174 doi "https://doi.org/10.1186/s12885-018-4716-8" @default.
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