Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887767886> ?p ?o ?g. }
- W2887767886 endingPage "5256" @default.
- W2887767886 startingPage "5247" @default.
- W2887767886 abstract "GW182 and argonaute 2 (AGO2) are core proteins of the RNA interference complex. GW182 is a scaffolding protein that physically associates with AGO2 and bridges its interactions with other proteins. A fundamental problem in biology is how scaffolding proteins adapt or contribute to differing functional demands within cells. Here we test the necessity for human GW182 proteins (paralogs TNRC6A, TNRC6B, and TNRC6C) for several mechanisms of small duplex RNA-mediated control of gene expression, including translational silencing by miRNAs, translational silencing by siRNAs, transcriptional silencing, transcriptional activation, and splicing. We find that GW182 is required for transcriptional activation and for the activity of miRNAs but is dispensable for the regulation of splicing, transcriptional silencing, and the action of siRNAs. AGO2, by contrast, is necessary for each of these processes. Our data suggest that GW182 does not alter AGO2 to make it active. Instead, GW182 organizes protein complexes around AGO2. Sometimes this higher level of organization is necessary, and sometimes it is not. AGO2 and GW182 offer an example for how a partnership between a scaffolding protein and a functional protein can be powerful but not obligatory." @default.
- W2887767886 created "2018-08-22" @default.
- W2887767886 creator A5023791554 @default.
- W2887767886 creator A5035282947 @default.
- W2887767886 creator A5044865944 @default.
- W2887767886 date "2018-08-07" @default.
- W2887767886 modified "2023-10-05" @default.
- W2887767886 title "The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing" @default.
- W2887767886 cites W127495262 @default.
- W2887767886 cites W1611419331 @default.
- W2887767886 cites W1744683414 @default.
- W2887767886 cites W1838945435 @default.
- W2887767886 cites W1920584780 @default.
- W2887767886 cites W1976840413 @default.
- W2887767886 cites W1980945502 @default.
- W2887767886 cites W1999605403 @default.
- W2887767886 cites W2003931886 @default.
- W2887767886 cites W2005300549 @default.
- W2887767886 cites W2006173503 @default.
- W2887767886 cites W2011480379 @default.
- W2887767886 cites W2036628539 @default.
- W2887767886 cites W2037199116 @default.
- W2887767886 cites W2040135588 @default.
- W2887767886 cites W2048443894 @default.
- W2887767886 cites W2058982772 @default.
- W2887767886 cites W2067742553 @default.
- W2887767886 cites W2080423827 @default.
- W2887767886 cites W2085516557 @default.
- W2887767886 cites W2088503826 @default.
- W2887767886 cites W2088594850 @default.
- W2887767886 cites W2091123054 @default.
- W2887767886 cites W2097679787 @default.
- W2887767886 cites W2099383089 @default.
- W2887767886 cites W2101543035 @default.
- W2887767886 cites W2102424174 @default.
- W2887767886 cites W2105444747 @default.
- W2887767886 cites W2111831519 @default.
- W2887767886 cites W2118818674 @default.
- W2887767886 cites W2131623079 @default.
- W2887767886 cites W2132691262 @default.
- W2887767886 cites W2132719798 @default.
- W2887767886 cites W2132888671 @default.
- W2887767886 cites W2134479420 @default.
- W2887767886 cites W2139871850 @default.
- W2887767886 cites W2144645374 @default.
- W2887767886 cites W2146763669 @default.
- W2887767886 cites W2148008586 @default.
- W2887767886 cites W2152946647 @default.
- W2887767886 cites W2152983548 @default.
- W2887767886 cites W2154227209 @default.
- W2887767886 cites W2158010566 @default.
- W2887767886 cites W2163298186 @default.
- W2887767886 cites W2175262244 @default.
- W2887767886 cites W2235287361 @default.
- W2887767886 cites W2329281045 @default.
- W2887767886 cites W2329920508 @default.
- W2887767886 cites W2411634967 @default.
- W2887767886 cites W2588486271 @default.
- W2887767886 cites W2745064085 @default.
- W2887767886 cites W2748344419 @default.
- W2887767886 cites W2793078357 @default.
- W2887767886 cites W2794930816 @default.
- W2887767886 doi "https://doi.org/10.1021/acs.biochem.8b00602" @default.
- W2887767886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6124307" @default.
- W2887767886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30086238" @default.
- W2887767886 hasPublicationYear "2018" @default.
- W2887767886 type Work @default.
- W2887767886 sameAs 2887767886 @default.
- W2887767886 citedByCount "18" @default.
- W2887767886 countsByYear W28877678862019 @default.
- W2887767886 countsByYear W28877678862020 @default.
- W2887767886 countsByYear W28877678862021 @default.
- W2887767886 countsByYear W28877678862022 @default.
- W2887767886 countsByYear W28877678862023 @default.
- W2887767886 crossrefType "journal-article" @default.
- W2887767886 hasAuthorship W2887767886A5023791554 @default.
- W2887767886 hasAuthorship W2887767886A5035282947 @default.
- W2887767886 hasAuthorship W2887767886A5044865944 @default.
- W2887767886 hasBestOaLocation W28877678862 @default.
- W2887767886 hasConcept C104317684 @default.
- W2887767886 hasConcept C119056186 @default.
- W2887767886 hasConcept C155330019 @default.
- W2887767886 hasConcept C188172738 @default.
- W2887767886 hasConcept C201853390 @default.
- W2887767886 hasConcept C22615655 @default.
- W2887767886 hasConcept C54355233 @default.
- W2887767886 hasConcept C54458228 @default.
- W2887767886 hasConcept C60723119 @default.
- W2887767886 hasConcept C67705224 @default.
- W2887767886 hasConcept C86803240 @default.
- W2887767886 hasConcept C95444343 @default.
- W2887767886 hasConceptScore W2887767886C104317684 @default.
- W2887767886 hasConceptScore W2887767886C119056186 @default.
- W2887767886 hasConceptScore W2887767886C155330019 @default.
- W2887767886 hasConceptScore W2887767886C188172738 @default.
- W2887767886 hasConceptScore W2887767886C201853390 @default.
- W2887767886 hasConceptScore W2887767886C22615655 @default.
- W2887767886 hasConceptScore W2887767886C54355233 @default.