FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887773485> ?p ?o ?g. }

• W2887773485 endingPage "3871" @default.
• W2887773485 startingPage "3866" @default.
• W2887773485 abstract "Hypoglycemia activates the counterregulatory response (CRR), a neural-endocrine reflex that restores euglycemia. Although effective if occasionally activated, repeated induction of the CRR leads to a decline in responsiveness and prolonged exposure to hypoglycemia. The mechanism underlying this impairment is not known. We found that the reduction in epinephrine release that characterizes a suppressed CRR involves a long-lasting form of sympatho-adrenal synaptic plasticity. Using optogenetically evoked catecholamine release, we show that recurrent hypoglycemia reduced the secretory capacity of mouse adrenal chromaffin cells. Single activation of the CRR increased the adrenal levels of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, but this was prevented by repeated activation. In contrast, the level of neuropeptide Y (NPY), an adrenal cotransmitter, remained elevated after recurrent hypoglycemia. Inhibition of NPY or Y1 signaling, either transgenically or pharmacologically, prevented the attenuation of both TH expression and epinephrine release. These results indicate that impairment of the CRR involves suppressed activity at the adrenal level. Interfering with the peripheral NPY-dependent negative feedback loop may provide a way to avoid the pathophysiological consequences of recurrent hypoglycemia which are common in the diabetic state." @default.
• W2887773485 created "2018-08-22" @default.
• W2887773485 creator A5046225712 @default.
• W2887773485 creator A5070178572 @default.
• W2887773485 creator A5072309689 @default.
• W2887773485 creator A5083042078 @default.
• W2887773485 creator A5087652752 @default.
• W2887773485 date "2018-08-06" @default.
• W2887773485 modified "2023-10-16" @default.
• W2887773485 title "Recurrent hypoglycemia inhibits the counterregulatory response by suppressing adrenal activity" @default.
• W2887773485 cites W1970225575 @default.
• W2887773485 cites W1975383771 @default.
• W2887773485 cites W1987132873 @default.
• W2887773485 cites W2008369080 @default.
• W2887773485 cites W2032882224 @default.
• W2887773485 cites W2033641935 @default.
• W2887773485 cites W2041564029 @default.
• W2887773485 cites W2077354310 @default.
• W2887773485 cites W2084287610 @default.
• W2887773485 cites W2099715459 @default.
• W2887773485 cites W2100356236 @default.
• W2887773485 cites W2111318745 @default.
• W2887773485 cites W2126940622 @default.
• W2887773485 cites W2127694005 @default.
• W2887773485 cites W2130749567 @default.
• W2887773485 cites W2131997797 @default.
• W2887773485 cites W2141655027 @default.
• W2887773485 cites W2142654426 @default.
• W2887773485 cites W2152297831 @default.
• W2887773485 cites W2156076680 @default.
• W2887773485 cites W2161639078 @default.
• W2887773485 cites W2165354335 @default.
• W2887773485 cites W2165907640 @default.
• W2887773485 cites W2167321173 @default.
• W2887773485 cites W2175302995 @default.
• W2887773485 cites W2236315019 @default.
• W2887773485 cites W2299515059 @default.
• W2887773485 cites W2337880278 @default.
• W2887773485 cites W2346661605 @default.
• W2887773485 cites W2590617299 @default.
• W2887773485 cites W1987062245 @default.
• W2887773485 doi "https://doi.org/10.1172/jci91921" @default.
• W2887773485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6118578" @default.
• W2887773485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30080182" @default.
• W2887773485 hasPublicationYear "2018" @default.
• W2887773485 type Work @default.
• W2887773485 sameAs 2887773485 @default.
• W2887773485 citedByCount "19" @default.
• W2887773485 countsByYear W28877734852018 @default.
• W2887773485 countsByYear W28877734852019 @default.
• W2887773485 countsByYear W28877734852020 @default.
• W2887773485 countsByYear W28877734852021 @default.
• W2887773485 countsByYear W28877734852022 @default.
• W2887773485 countsByYear W28877734852023 @default.
• W2887773485 crossrefType "journal-article" @default.
• W2887773485 hasAuthorship W2887773485A5046225712 @default.
• W2887773485 hasAuthorship W2887773485A5070178572 @default.
• W2887773485 hasAuthorship W2887773485A5072309689 @default.
• W2887773485 hasAuthorship W2887773485A5083042078 @default.
• W2887773485 hasAuthorship W2887773485A5087652752 @default.
• W2887773485 hasBestOaLocation W28877734851 @default.
• W2887773485 hasConcept C118303440 @default.
• W2887773485 hasConcept C126322002 @default.
• W2887773485 hasConcept C134018914 @default.
• W2887773485 hasConcept C159167319 @default.
• W2887773485 hasConcept C170493617 @default.
• W2887773485 hasConcept C2775859304 @default.
• W2887773485 hasConcept C2775894120 @default.
• W2887773485 hasConcept C2777597313 @default.
• W2887773485 hasConcept C2779306644 @default.
• W2887773485 hasConcept C2780668416 @default.
• W2887773485 hasConcept C2780910648 @default.
• W2887773485 hasConcept C513476851 @default.
• W2887773485 hasConcept C71924100 @default.
• W2887773485 hasConcept C93984277 @default.
• W2887773485 hasConceptScore W2887773485C118303440 @default.
• W2887773485 hasConceptScore W2887773485C126322002 @default.
• W2887773485 hasConceptScore W2887773485C134018914 @default.
• W2887773485 hasConceptScore W2887773485C159167319 @default.
• W2887773485 hasConceptScore W2887773485C170493617 @default.
• W2887773485 hasConceptScore W2887773485C2775859304 @default.
• W2887773485 hasConceptScore W2887773485C2775894120 @default.
• W2887773485 hasConceptScore W2887773485C2777597313 @default.
• W2887773485 hasConceptScore W2887773485C2779306644 @default.
• W2887773485 hasConceptScore W2887773485C2780668416 @default.
• W2887773485 hasConceptScore W2887773485C2780910648 @default.
• W2887773485 hasConceptScore W2887773485C513476851 @default.
• W2887773485 hasConceptScore W2887773485C71924100 @default.
• W2887773485 hasConceptScore W2887773485C93984277 @default.
• W2887773485 hasFunder F4320332161 @default.
• W2887773485 hasIssue "9" @default.
• W2887773485 hasLocation W28877734851 @default.
• W2887773485 hasLocation W28877734852 @default.
• W2887773485 hasLocation W28877734853 @default.
• W2887773485 hasLocation W28877734854 @default.
• W2887773485 hasOpenAccess W2887773485 @default.
• W2887773485 hasPrimaryLocation W28877734851 @default.
• W2887773485 hasRelatedWork W1964296834 @default.

• next